排列检验在生物品尝学中的两个应用。

Luis León-Novelo, Kaisa M Kemppainen, Alexandria Ardissone, Austin Davis-Richardson, Jennie Fagen, Kelsey Gano, Eric W Triplett
{"title":"排列检验在生物品尝学中的两个应用。","authors":"Luis León-Novelo, Kaisa M Kemppainen, Alexandria Ardissone, Austin Davis-Richardson, Jennie Fagen, Kelsey Gano, Eric W Triplett","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>We show two examples of how we answer biological questions by converting them into statistical hypothesis testing problems. We consider gene abundance data, and apply permutation tests. Though these tests are simple, they allow us to test biologically relevant hypotheses. Here we present the analysis of data rising from two studies on Type 1 Diabetes. In the first study [3] are interested in comparing the gut bacterial biodiversity in children at risk and not at risk of developing diabetes. In the second study, [4] compare the gut bacterial biodiversity of children in six different sites in USA and Europe. The statistical analyses presented here are parts of the \"statistical methods\" in two papers mentioned above. Here we offer a detailed explanation of the \"Statistical Methods\" addressed to readers with a statistics background.</p>","PeriodicalId":93912,"journal":{"name":"Boletin de la Sociedad Matematica Mexicana","volume":"19 2","pages":"255-266"},"PeriodicalIF":0.0000,"publicationDate":"2013-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4159102/pdf/nihms-608319.pdf","citationCount":"0","resultStr":"{\"title\":\"TWO APPLICATIONS OF PERMUTATION TESTS IN BIOSTASTICS.\",\"authors\":\"Luis León-Novelo, Kaisa M Kemppainen, Alexandria Ardissone, Austin Davis-Richardson, Jennie Fagen, Kelsey Gano, Eric W Triplett\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>We show two examples of how we answer biological questions by converting them into statistical hypothesis testing problems. We consider gene abundance data, and apply permutation tests. Though these tests are simple, they allow us to test biologically relevant hypotheses. Here we present the analysis of data rising from two studies on Type 1 Diabetes. In the first study [3] are interested in comparing the gut bacterial biodiversity in children at risk and not at risk of developing diabetes. In the second study, [4] compare the gut bacterial biodiversity of children in six different sites in USA and Europe. The statistical analyses presented here are parts of the \\\"statistical methods\\\" in two papers mentioned above. Here we offer a detailed explanation of the \\\"Statistical Methods\\\" addressed to readers with a statistics background.</p>\",\"PeriodicalId\":93912,\"journal\":{\"name\":\"Boletin de la Sociedad Matematica Mexicana\",\"volume\":\"19 2\",\"pages\":\"255-266\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2013-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4159102/pdf/nihms-608319.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Boletin de la Sociedad Matematica Mexicana\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Boletin de la Sociedad Matematica Mexicana","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

我们展示了两个例子,说明我们如何通过将生物学问题转化为统计假设检验问题来回答这些问题。我们考虑基因丰度数据,并应用排列检验。尽管这些测试很简单,但它们使我们能够测试与生物学相关的假设。在这里,我们对两项1型糖尿病研究的数据进行分析。在第一项研究[3]中,我们感兴趣的是比较有糖尿病风险和没有糖尿病风险的儿童的肠道细菌生物多样性。在第二项研究中,[4]比较了美国和欧洲六个不同地区儿童的肠道细菌生物多样性。这里介绍的统计分析是上述两篇论文中“统计方法”的一部分。在这里,我们向有统计学背景的读者详细解释“统计方法”。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

摘要图片

摘要图片

摘要图片

分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
TWO APPLICATIONS OF PERMUTATION TESTS IN BIOSTASTICS.

We show two examples of how we answer biological questions by converting them into statistical hypothesis testing problems. We consider gene abundance data, and apply permutation tests. Though these tests are simple, they allow us to test biologically relevant hypotheses. Here we present the analysis of data rising from two studies on Type 1 Diabetes. In the first study [3] are interested in comparing the gut bacterial biodiversity in children at risk and not at risk of developing diabetes. In the second study, [4] compare the gut bacterial biodiversity of children in six different sites in USA and Europe. The statistical analyses presented here are parts of the "statistical methods" in two papers mentioned above. Here we offer a detailed explanation of the "Statistical Methods" addressed to readers with a statistics background.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
期刊最新文献
Fixed points of $$(\varphi ,F)$$-weak contractions on metric-like spaces with applications to integral equations on time scales The coreflective hull of $$\mathcal {U}$$-Fréchet spaces Algebra generated by Toeplitz operators with $${\mathbb {T}}$$-invariant symbols An $$\mathrm {SL}(n)$$-invariant mixed integral $$L_p$$ affine surface area The second and third-order Hermitian Toeplitz determinants for starlike and convex functions of order $$\alpha $$
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1