日本非酒精性脂肪肝患者AST/ALT与2型糖尿病发病率相关性的性别差异：一项回顾性队列研究。

IF 1.5 4区医学 Q4 ENDOCRINOLOGY & METABOLISM Endocrine Research Pub Date : 2024-01-02 Epub Date: 2024-01-04 DOI:10.1080/07435800.2023.2262034

Cong Zhang, Qian Xu, Chengye Xu, Kun Yang, Tian Xia, Wuying Hasi, Ming Hao, Hongyu Kuang

{"title":"日本非酒精性脂肪肝患者AST/ALT与2型糖尿病发病率相关性的性别差异：一项回顾性队列研究。","authors":"Cong Zhang, Qian Xu, Chengye Xu, Kun Yang, Tian Xia, Wuying Hasi, Ming Hao, Hongyu Kuang","doi":"10.1080/07435800.2023.2262034","DOIUrl":null,"url":null,"abstract":"Objectives/introduction: The purpose of the current study was to investigate the association between Aspartate Transaminase (AST)/Alanine transaminase(ALT) and type 2 diabetes (T2DM) in nonalcoholic fatty liver disease (NAFLD) patients and to determine whether there were sex differences.Methods: In the retrospective study, we collected data on NAFLD patients (1, 896 men and 465 women) at Murakami Memorial Hospital from 2004 to 2015. Data were stratified by sex to investigate the association between AST/ALT and T2DM incidence by sex. Multiple regression analysis, smooth curve fitting model and subgroup analysis were used to determine the correlation, non-linear relationship and threshold effect between AST/ALT and T2DM.Results: In our study, 157 men and 40 women developed T2DM at follow-up. After adjusting for risk factors, AST/ALT was significantly associated with T2DM in men with NAFLD but not in women with NAFLD. The risk of T2DM increased as the AST/ALT ratio decreased. Besides, in male NAFLD patients, AST/ALT showed a non-linear relationship with T2DM, with an inflection point value of 0.964. When the AST to ALT ratio was below the threshold (AST/ALT <0.964), AST/ALT was significantly negatively associated with T2DM (HR = 0.177, 95% CI 0.055-0.568; P = 0.0036). In contrast, when AST/ALT >0.964, no significant association was found (HR = 3.174, 95% CI 0.345-29.167; P = 0.3074). Moreover, subgroup analysis showed that GGT could alter the relationship between AST/ALT and T2DM. In the group with GGT ≤ 40, AST/ALT was strongly associated with T2DM (HR = 0.24, 95% CI 0.09-0.66; P = 0.0059).Conclusions: These results suggested that there were sex differences in the association between AST/ALT and T2DM in NAFLD participants. A non-linear association between AST/ALT and T2DM was observed in males. AST/ALT in the normal GGT group (GGT ≤40) might better facilitate the early screening of T2DM.","PeriodicalId":11601,"journal":{"name":"Endocrine Research","volume":" ","pages":"1-11"},"PeriodicalIF":1.5000,"publicationDate":"2024-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Sex Differences in the Association Between AST/ALT and Incidence of Type 2 Diabetes in Japanese Patients with Nonalcoholic Fatty Liver Disease: A Retrospective Cohort Study.\",\"authors\":\"Cong Zhang, Qian Xu, Chengye Xu, Kun Yang, Tian Xia, Wuying Hasi, Ming Hao, Hongyu Kuang\",\"doi\":\"10.1080/07435800.2023.2262034\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Objectives/introduction: The purpose of the current study was to investigate the association between Aspartate Transaminase (AST)/Alanine transaminase(ALT) and type 2 diabetes (T2DM) in nonalcoholic fatty liver disease (NAFLD) patients and to determine whether there were sex differences.Methods: In the retrospective study, we collected data on NAFLD patients (1, 896 men and 465 women) at Murakami Memorial Hospital from 2004 to 2015. Data were stratified by sex to investigate the association between AST/ALT and T2DM incidence by sex. Multiple regression analysis, smooth curve fitting model and subgroup analysis were used to determine the correlation, non-linear relationship and threshold effect between AST/ALT and T2DM.Results: In our study, 157 men and 40 women developed T2DM at follow-up. After adjusting for risk factors, AST/ALT was significantly associated with T2DM in men with NAFLD but not in women with NAFLD. The risk of T2DM increased as the AST/ALT ratio decreased. Besides, in male NAFLD patients, AST/ALT showed a non-linear relationship with T2DM, with an inflection point value of 0.964. When the AST to ALT ratio was below the threshold (AST/ALT <0.964), AST/ALT was significantly negatively associated with T2DM (HR = 0.177, 95% CI 0.055-0.568; P = 0.0036). In contrast, when AST/ALT >0.964, no significant association was found (HR = 3.174, 95% CI 0.345-29.167; P = 0.3074). Moreover, subgroup analysis showed that GGT could alter the relationship between AST/ALT and T2DM. In the group with GGT ≤ 40, AST/ALT was strongly associated with T2DM (HR = 0.24, 95% CI 0.09-0.66; P = 0.0059).Conclusions: These results suggested that there were sex differences in the association between AST/ALT and T2DM in NAFLD participants. A non-linear association between AST/ALT and T2DM was observed in males. AST/ALT in the normal GGT group (GGT ≤40) might better facilitate the early screening of T2DM.\",\"PeriodicalId\":11601,\"journal\":{\"name\":\"Endocrine Research\",\"volume\":\" \",\"pages\":\"1-11\"},\"PeriodicalIF\":1.5000,\"publicationDate\":\"2024-01-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Endocrine Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1080/07435800.2023.2262034\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/1/4 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q4\",\"JCRName\":\"ENDOCRINOLOGY & METABOLISM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Endocrine Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/07435800.2023.2262034","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/4 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}

引用次数: 0

摘要

目的/简介：本研究的目的是调查非酒精性脂肪肝（NAFLD）患者的天冬氨酸转氨酶（AST）/丙氨酸转氨酶（ALT）与2型糖尿病（T2DM）之间的关系，并确定是否存在性别差异。方法：在回顾性研究中，我们收集了2004年至2015年村上纪念医院NAFLD患者（1896名男性和465名女性）的数据。按性别对数据进行分层，以调查AST/ALT与按性别划分的T2DM发病率之间的关系。采用多元回归分析、平滑曲线拟合模型和亚组分析方法，确定AST/ALT与T2DM的相关性、非线性关系和阈值效应。结果：在我们的研究中，157名男性和40名女性在随访中发展为T2DM。在校正了风险因素后，AST/ALT与NAFLD男性T2DM显著相关，但与NAFLD女性无关。2型糖尿病的风险随着AST/ALT比值的降低而增加。此外，在男性NAFLD患者中，AST/ALT与T2DM呈非线性关系，拐点值为0.964。当AST与ALT比值低于阈值时（AST/ALTP = 0.0036）。相反，当AST/ALT>0.964时，没有发现显著的相关性（HR = 3.174，95%CI 0.345-29.167；P = 0.3074）。亚组分析表明GGT可改变AST/ALT与T2DM的关系。GGT组 ≤ 40，AST/ALT与T2DM密切相关（HR = 0.24，95%CI 0.09-0.66；P = 0.0059）。结论：这些结果表明，在NAFLD参与者中，AST/ALT与T2DM之间的相关性存在性别差异。在男性中观察到AST/ALT和T2DM之间的非线性关联。正常GGT组（GGT≤40）AST/ALT有利于早期筛查T2DM。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

Sex Differences in the Association Between AST/ALT and Incidence of Type 2 Diabetes in Japanese Patients with Nonalcoholic Fatty Liver Disease: A Retrospective Cohort Study.

Objectives/introduction: The purpose of the current study was to investigate the association between Aspartate Transaminase (AST)/Alanine transaminase(ALT) and type 2 diabetes (T2DM) in nonalcoholic fatty liver disease (NAFLD) patients and to determine whether there were sex differences.

Methods: In the retrospective study, we collected data on NAFLD patients (1, 896 men and 465 women) at Murakami Memorial Hospital from 2004 to 2015. Data were stratified by sex to investigate the association between AST/ALT and T2DM incidence by sex. Multiple regression analysis, smooth curve fitting model and subgroup analysis were used to determine the correlation, non-linear relationship and threshold effect between AST/ALT and T2DM.

Results: In our study, 157 men and 40 women developed T2DM at follow-up. After adjusting for risk factors, AST/ALT was significantly associated with T2DM in men with NAFLD but not in women with NAFLD. The risk of T2DM increased as the AST/ALT ratio decreased. Besides, in male NAFLD patients, AST/ALT showed a non-linear relationship with T2DM, with an inflection point value of 0.964. When the AST to ALT ratio was below the threshold (AST/ALT <0.964), AST/ALT was significantly negatively associated with T2DM (HR = 0.177, 95% CI 0.055-0.568; P = 0.0036). In contrast, when AST/ALT >0.964, no significant association was found (HR = 3.174, 95% CI 0.345-29.167; P = 0.3074). Moreover, subgroup analysis showed that GGT could alter the relationship between AST/ALT and T2DM. In the group with GGT ≤ 40, AST/ALT was strongly associated with T2DM (HR = 0.24, 95% CI 0.09-0.66; P = 0.0059).

Conclusions: These results suggested that there were sex differences in the association between AST/ALT and T2DM in NAFLD participants. A non-linear association between AST/ALT and T2DM was observed in males. AST/ALT in the normal GGT group (GGT ≤40) might better facilitate the early screening of T2DM.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Endocrine Research 医学-内分泌学与代谢

CiteScore

4.30

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： This journal publishes original articles relating to endocrinology in the broadest context. Subjects of interest include: receptors and mechanism of action of hormones, methodological advances in the detection and measurement of hormones; structure and chemical properties of hormones. Invitations to submit Brief Reviews are issued to specific authors by the Editors.

期刊最新文献

Association Between Serum Uric Acid and Pregnancy Outcomes: A Study in Chinese Women. Pancreatic β-Cells, Diabetes and Autophagy. Antithyroid Antibodies and Reproductive Parameters of Women with Hashimoto's Thyroiditis. Adverse Events of Adjuvant Mitotane Treatment for Adrenocortical Carcinoma Treatment Outcomes in Patients with Recurrent Adrenocortical Carcinoma.