粪便微生物群移植治疗复发性艰难梭菌感染：连续病例系列的围手术期方法。

IF 1.3 4区医学 Q4 GASTROENTEROLOGY & HEPATOLOGY Acta gastro-enterologica Belgica Pub Date : 2023-07-01 DOI:10.51821/86.3.11795

K Korpak, L Defourny, S Lali, M Delvallée, R Demeester, E Toussaint

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引用次数: 1

摘要

背景：粪便微生物群移植（FMT）对复发性艰难梭菌感染（CDI）具有很高的疗效。尽管这种疗法的使用越来越多，但诊断和治疗之间的延迟是过度的。此外，捐助者的选择是一个重要而耗时的过程。方法：我们回顾了2015年至2022年间在CHU Charleroi医院接受FMT治疗复发性CDI的患者。报告了一般情况、给药类型、不良事件和供体选择。FMT采用胃十二指肠镜、结肠镜和新鲜或冷冻材料灌肠进行。结果：10例合并多种疾病的患者均接受FMT治疗。7名患者在一次手术后治愈。一名患者在更换为无关供体后成功治愈，初步疗效已确定。结论：FMT是一种有效的治疗方法，应在治疗的早期阶段加以考虑。粪便捐献者应彻底筛查传染病和其他与微生物群组成有关的标准。

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Treatment of recurrent Clostridioides difficile infections with faecal microbiota transplantation: peri-procedural methods in a consecutive case series.

Background: Faecal microbiota transplantation (FMT) has high efficacy against recurrent Clostridioides difficile infection (CDI). Despite the increasing use of this therapy, the delay between diagnosis and treatment is excessive. Furthermore, donor selection is an important and time-consuming process.

Methods: We reviewed patients who underwent FMT for recurrent CDI at the CHU Charleroi Hospital between 2015 and 2022. The general context, type of administration, adverse events, and donor selection were reported. FMT was conducted using gastroduodenoscopy, colonoscopy, and enema with either fresh or frozen material.

Results: Ten patients with multiple comorbidities were treated by FMT. Seven patients were cured after one procedure. One patient was successfully cured after a change to an unrelated donor, and preliminary efficacy was established.

Conclusions: FMT is an effective treatment that should be considered during the earlier phases of treatment. Stool donors should be thoroughly screened for infectious diseases and other criteria related to microbiota composition.

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来源期刊

Acta gastro-enterologica Belgica Medicine-Gastroenterology

CiteScore

2.30

自引率

20.00%

发文量

期刊介绍： The Journal Acta Gastro-Enterologica Belgica principally publishes peer-reviewed original manuscripts, reviews, letters to editors, book reviews and guidelines in the field of clinical Gastroenterology and Hepatology, including digestive oncology, digestive pathology, as well as nutrition. Pure animal or in vitro work will not be considered for publication in the Journal. Translational research papers (including sections of animal or in vitro work) are considered by the Journal if they have a clear relationship to or relevance for clinical hepato-gastroenterology (screening, disease mechanisms and/or new therapies). Case reports and clinical images will be accepted if they represent an important contribution to the description, the pathogenesis or the treatment of a specific gastroenterology or liver problem. The language of the Journal is English. Papers from any country will be considered for publication. Manuscripts submitted to the Journal should not have been published previously (in English or any other language), nor should they be under consideration for publication elsewhere. Unsolicited papers are peer-reviewed before it is decided whether they should be accepted, rejected, or returned for revision. Manuscripts that do not meet the presentation criteria (as indicated below) will be returned to the authors. Papers that go too far beyond the scope of the journal will be also returned to the authors by the editorial board generally within 2 weeks. The Journal reserves the right to edit the language of papers accepted for publication for clarity and correctness, and to make formal changes to ensure compliance with AGEB’s style. Authors have the opportunity to review such changes in the proofs.