Eosinophilic-Associated Disease Overlap: What Do We Know About It?

https://e-aair.org Over the past two decades, it was discovered that a range of inflammatory diseases involving several organ systems with elevated eosinophil counts in blood and/or tissue was primarily driven by abnormal regulation of the number and activation state of eosinophils.1-11 Eosinophil-associated diseases (EADs) refer to these heterogeneous conditions in which eosinophils are believed to play critical pathological roles.1,12-14 EADs encompass common respiratory and dermatologic conditions, such as asthma,3-5 chronic rhinosinusitis with nasal polyps,6 and atopic dermatitis,7 less common eosinophilic gastrointestinal diseases,8 and rare conditions including allergic bronchopulmonary aspergillosis (ABPA),9 eosinophilic granulomatosis with polyangiitis (EGPA)1 and hypereosinophilic syndromes (HES).10