The Role of TRIM24 in Allergic Rhinitis.

https://e-aair.org Allergic rhinitis (AR) is a common inflammatory disease characterized by rhinorrhea, nasal obstruction, sneezing, and itchy nose. The inflammation of nasal mucosa is ultimately caused by an exposure to allergens and immunoglobulin (Ig) E-mediated sensitization, in which T helper type 2 (Th2) cells and cytokines—interleukin (IL)-4, IL-5, and IL-13—play an important role.1,2 IL-4 is crucial in activating Janus kinase (JAK), which phosphorylates transcription factor, signal transducer and activator of transcription 6 (STAT6), a key factor for Th2 polarization.3,4 On the other hand, tripartite motif-containing 24 (TRIM24), promotes STAT6 acetylation by catalyzing the ubiquitination of cAMP-responsive elementbinding protein (CREB)-binding protein at Lys 119.5 Previous studies have proposed the role of TRIM24 in other diseases, such as head and neck squamous cell carcinoma,6 prostate cancer,7 and breast cancer.8 However, its role in AR has not been explored.