{"title":"益生菌预防或治疗狗胃肠道疾病的临床效果:系统综述。","authors":"Anders P Jensen, Charlotte R Bjørnvad","doi":"10.1111/jvim.15554","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Gastrointestinal diseases are prevalent in dogs, and probiotics could provide safe alternatives to conventional treatments.</p><p><strong>Objective: </strong>To evaluate the clinical effects of probiotics when used in the prevention or treatment of gastrointestinal disease in dogs compared with no treatment, only symptomatic treatment, or conventional treatment.</p><p><strong>Methods: </strong>A systematic review was preformed searching AGRICOLA, AGRIS, CAB Abstracts, Embase, Ovid MEDLINE, and Web of Science to identify articles published before April 1, 2017. Selection criteria were original research report, those published in peer reviewed journal, and study investigating in vivo use of probiotic for prevention or treatment of gastrointestinal disease in dogs. Studies were rated based on the level of evidence, and methodological quality was evaluated by the following variables: similarities between groups at baseline, risk of bias, and study group size.</p><p><strong>Results: </strong>One hundred sixty-five studies were identified, of which 17 met the inclusion criteria-12 concerned acute gastrointestinal disease and 5 concerned chronic gastrointestinal disease. The level of evidence ranged between randomized controlled studies and crossover uncontrolled trials; estimated risk of bias was generally moderate to high; and sample sizes were small. Feces consistency was the most frequently evaluated clinical variable.</p><p><strong>Conclusions and clinical importance: </strong>The current data point toward a very limited and possibly clinically unimportant effect for prevention or treatment of acute gastrointestinal disease. For chronic gastrointestinal disease, dietary intervention remains the major key in treatment, whereas probiotic supplement seems not to add significant improvement. 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引用次数: 31
摘要
背景:胃肠道疾病在狗身上很普遍,益生菌可以提供传统治疗的安全替代品。目的:评价益生菌在预防或治疗狗胃肠道疾病时与不治疗、仅对症治疗或常规治疗相比的临床效果。方法:检索AGRICOLA、AGRIS、CAB Abstracts、Embase、Ovid MEDLINE和Web of Science进行系统综述,以确定2017年4月1日之前发表的文章。选择标准是原始研究报告、发表在同行评审期刊上的报告,以及研究益生菌在体内用于预防或治疗狗胃肠道疾病的研究。根据证据水平对研究进行评级,并通过以下变量评估方法质量:基线时各组之间的相似性、偏倚风险和研究组规模。结果:确定了165项研究,其中17项符合纳入标准,12项涉及急性胃肠道疾病,5项涉及慢性胃肠道疾病。证据水平介于随机对照研究和交叉对照试验之间;估计的偏倚风险一般为中度至高度;并且样本量较小。粪便一致性是最常评估的临床变量。结论和临床重要性:目前的数据表明,预防或治疗急性胃肠道疾病的效果非常有限,可能在临床上不重要。对于慢性胃肠道疾病,饮食干预仍然是治疗的主要关键,而益生菌补充剂似乎没有显著改善。然而,研究往往动力不足,强调了未来更大规模、最好是多中心研究的必要性。
Clinical effect of probiotics in prevention or treatment of gastrointestinal disease in dogs: A systematic review.
Background: Gastrointestinal diseases are prevalent in dogs, and probiotics could provide safe alternatives to conventional treatments.
Objective: To evaluate the clinical effects of probiotics when used in the prevention or treatment of gastrointestinal disease in dogs compared with no treatment, only symptomatic treatment, or conventional treatment.
Methods: A systematic review was preformed searching AGRICOLA, AGRIS, CAB Abstracts, Embase, Ovid MEDLINE, and Web of Science to identify articles published before April 1, 2017. Selection criteria were original research report, those published in peer reviewed journal, and study investigating in vivo use of probiotic for prevention or treatment of gastrointestinal disease in dogs. Studies were rated based on the level of evidence, and methodological quality was evaluated by the following variables: similarities between groups at baseline, risk of bias, and study group size.
Results: One hundred sixty-five studies were identified, of which 17 met the inclusion criteria-12 concerned acute gastrointestinal disease and 5 concerned chronic gastrointestinal disease. The level of evidence ranged between randomized controlled studies and crossover uncontrolled trials; estimated risk of bias was generally moderate to high; and sample sizes were small. Feces consistency was the most frequently evaluated clinical variable.
Conclusions and clinical importance: The current data point toward a very limited and possibly clinically unimportant effect for prevention or treatment of acute gastrointestinal disease. For chronic gastrointestinal disease, dietary intervention remains the major key in treatment, whereas probiotic supplement seems not to add significant improvement. However, studies were often underpowered, underscoring the need for future larger, preferably multicenter studies.
期刊介绍:
The mission of the Journal of Veterinary Internal Medicine is to advance veterinary medical knowledge and improve the lives of animals by publication of authoritative scientific articles of animal diseases.