病毒受体相互作用:溶瘤病毒发展的结构见解。

IF 6.7 Oncolytic Virotherapy Pub Date : 2019-10-29 eCollection Date: 2019-01-01 DOI:10.2147/OV.S218494
Nadishka Jayawardena, Laura N Burga, John T Poirier, Mihnea Bostina
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引用次数: 22

摘要

溶瘤病毒治疗的最新进展特别关注开发用溶瘤病毒(OVs)靶向癌症细胞的新策略。病毒包膜或外壳蛋白的修饰是将病毒重新用于癌症治疗的合理手段。在这篇综述中,我们讨论了OV及其天然受体之间相互作用的详细结构知识如何为一些病毒的肿瘤特异性和替代受体的重新靶向提供有价值的见解,以实现广泛的肿瘤嗜性或提高肿瘤选择性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Virus-Receptor Interactions: Structural Insights For Oncolytic Virus Development.

Recent advancements in oncolytic virotherapy commend a special attention to developing new strategies for targeting cancer cells with oncolytic viruses (OVs). Modifications of the viral envelope or coat proteins serve as a logical mean of repurposing viruses for cancer treatment. In this review, we discuss how detailed structural knowledge of the interactions between OVs and their natural receptors provide valuable insights into tumor specificity of some viruses and re-targeting of alternate receptors for broad tumor tropism or improved tumor selectivity.

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