质子治疗中小动物辐射研究的临床前剂量测定:可行性研究。

IF 2.1 Q3 ONCOLOGY International Journal of Particle Therapy Pub Date : 2023-04-03 eCollection Date: 2023-01-01 DOI:10.14338/IJPT-22-00035.1
Fatih Biltekin, Christian Bäumer, Johannes Esser, Osamah Ghanem, Gokhan Ozyigit, Beate Timmermann
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引用次数: 0

摘要

目的:评价三维(3D)打印小动物模型在小动物放射研究质子治疗剂量验证中的可行性。材料和方法:使用真实大鼠和荷瘤小鼠的计算机断层扫描数据集,对两种不同的体模进行回顾性建模。大鼠模型设计用于容纳EBT3薄膜和电离室。皮下荷瘤小鼠模型仅被修改以适应胶片剂量测定。所有模型均使用聚乳酸(PLA)细丝进行打印。设置最佳打印参数以创建组织等效材料。然后,使用铅笔束扫描技术创建了不同解剖靶点的质子治疗计划,包括大鼠体模的全脑和全肺照射以及小鼠体模的皮下肿瘤模型。使用3D打印体模进行点剂量和胶片剂量测定。此外,从印刷精度和均匀性的角度对所有模型进行了分析。结果:三维打印的体模在体外具有良好的均匀性,打印精度在0.5mm以内。根据我们的研究结果,EBT3二维剂量测定显示,除全脑照射外,所有测量的γ通过率均处于可接受水平(γ通过率为89.8%)。在点剂量分析方面,结论:三维打印的小动物模型在小动物放射研究的临床质子治疗的剂量测定验证中显示出巨大的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Preclinical Dosimetry for Small Animal Radiation Research in Proton Therapy: A Feasibility Study.

Purpose: To evaluate the feasibility of the three-dimensional (3D) printed small animal phantoms in dosimetric verification of proton therapy for small animal radiation research.

Materials and methods: Two different phantoms were modeled using the computed-tomography dataset of real rat and tumor-bearing mouse, retrospectively. Rat phantoms were designed to accommodate both EBT3 film and ionization chamber. A subcutaneous tumor-bearing mouse phantom was only modified to accommodate film dosimetry. All phantoms were printed using polylactic-acid (PLA) filament. Optimal printing parameters were set to create tissue-equivalent material. Then, proton therapy plans for different anatomical targets, including whole brain and total lung irradiation in the rat phantom and the subcutaneous tumor model in the mouse phantom, were created using the pencil-beam scanning technique. Point dose and film dosimetry measurements were performed using 3D-printed phantoms. In addition, all phantoms were analyzed in terms of printing accuracy and uniformity.

Results: Three-dimensionally printed phantoms had excellent uniformity over the external body, and printing accuracy was within 0.5 mm. According to our findings, two-dimensional dosimetry with EBT3 showed acceptable levels of γ passing rate for all measurements except for whole brain irradiation (γ passing rate, 89.8%). In terms of point dose analysis, a good agreement (<0.1%) was found between the measured and calculated point doses for all anatomical targets.

Conclusion: Three-dimensionally printed small animal phantoms show great potential for dosimetric verifications of clinical proton therapy for small animal radiation research.

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来源期刊
International Journal of Particle Therapy
International Journal of Particle Therapy Medicine-Radiology, Nuclear Medicine and Imaging
CiteScore
3.70
自引率
5.90%
发文量
23
审稿时长
20 weeks
期刊最新文献
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