基于网络药理学和分子对接的青藤碱治疗过敏性鼻炎的潜在靶点和机制鉴定。

IF 0.8 4区 医学 Q4 IMMUNOLOGY Critical Reviews in Immunology Pub Date : 2023-01-01 DOI:10.1615/CritRevImmunol.2023049479
Xuemei Liu, Hong Chen, Xiaobo Chen, Peng Wu, Jianhua Zhang
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引用次数: 0

摘要

本研究旨在通过网络药理学和分子对接研究青藤碱治疗变应性鼻炎的潜在靶点和分子机制。青藤碱和AR的相关靶标从公共数据库中获得,AR的差异表达基因(DEGs)在基因表达综合数据库中鉴定。使用VennDiagram,我们通过交叉疾病靶点、药物靶点和DEG确定了青藤碱抗AR的22个潜在靶点。功能分析显示,青藤碱可能通过其抗炎和免疫抑制作用发挥作用,其作用途径可能包括MAPK、HIF-1和JAK-STAT途径。此外,使用EPC、MCC和MNC算法识别中枢靶标,并通过整合前10个中枢基因和22个潜在靶标来选择6个中枢靶标(STAT3、EGFR、NFKB1、HIF1A、PTGS2和JAK1)。分子对接分析表明,STAT3、EGFR、PTGS2和JAK1可能是青藤碱对抗AR的关键靶点。总之,我们的研究结果表明,青藤碱对AR具有潜在的治疗作用,其作用机制可能涉及炎症和免疫相关关键靶点和途径的调节。
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Identification of Potential Targets and Mechanisms of Sinomenine in Allergic Rhinitis Treatment Based on Network Pharmacology and Molecular Docking.

This study aimed to investigate the potential targets and molecular mechanism of sinomenine in treating allergic rhinitis (AR) using network pharmacology and molecular docking. Relevant targets of sinomenine and AR were obtained from public databases, and differentially expressed genes (DEGs) for AR were identified in the Gene Expression Omnibus database. Using VennDiagram, we identified 22 potential targets of sinomenine against AR by crossing disease targets, drug targets, and DEGs. Functional analysis revealed that sinomenine may act via its anti-inflammatory and immunosuppressive effects, and its action pathways may include the MAPK, HIF-1, and JAK-STAT pathways. Furthermore, hub targets were identified using EPC, MCC, and MNC algorithms, and six hub targets (STAT3, EGFR, NFKB1, HIF1A, PTGS2, and JAK1) were selected by integrating the top 10 hub genes and 22 potential targets. Molecular docking analysis indicated that STAT3, EGFR, PTGS2, and JAK1 may be key targets of sinomenine against AR. Overall, our results suggest that sinomenine has potential therapeutic effects against AR, and its mechanism of action may involve the regulation of key targets and pathways related to inflammation and immunity.

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来源期刊
CiteScore
2.60
自引率
0.00%
发文量
14
审稿时长
>12 weeks
期刊介绍: Immunology covers a broad spectrum of investigations at the genes, molecular, cellular, organ and system levels to reveal defense mechanisms against pathogens as well as protection against tumors and autoimmune diseases. The great advances in immunology in recent years make this field one of the most dynamic and rapidly growing in medical sciences. Critical ReviewsTM in Immunology (CRI) seeks to present a balanced overview of contemporary adaptive and innate immune responses related to autoimmunity, tumor, microbe, transplantation, neuroimmunology, immune regulation and immunotherapy from basic to translational aspects in health and disease. The articles that appear in CRI are mostly obtained by invitations to active investigators. But the journal will also consider proposals from the scientific community. Interested investigators should send their inquiries to the editor before submitting a manuscript.
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