肿瘤病毒治疗:癌症管理的先进微生物方法。

IF 1.5 4区 医学 Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Critical Reviews in Eukaryotic Gene Expression Pub Date : 2024-01-01 DOI:10.1615/CritRevEukaryotGeneExpr.2023048962
Muhammad Farhan Siddiq Rao, Bilal Ahmed, Muhammad Imran Qadir
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引用次数: 0

摘要

肿瘤(癌性)细胞的破坏可能是由活病毒引起的,活病毒具有复制能力并在肿瘤细胞中选择性复制,称为溶瘤病毒疗法。与保守的癌症治疗相比,肿瘤选择性复制病毒具有更大的优势。这些病毒为人类癌症的治疗引入了新的方法。在病毒治疗学的发展中使用了许多策略。病毒疗法并不是一个不寻常的概念,但溶瘤病毒基因修饰技术的现代进步提高了靶向肿瘤细胞的能力,更具体地说,它引发了对抗癌症的新型弹药的开发。一种有效的溶瘤病毒治疗方法在临床上显示出可行性和安全性。正在探索新的策略来克服病毒治疗中的基本障碍和挑战。从逻辑上讲,溶瘤病毒的使用将成功地增强针对多种肿瘤的新治疗方法。联合治疗显示的一些令人鼓舞的抗肿瘤反应正在激发对已确定的癌症的强大免疫力。溶瘤病毒治疗的主要进展已经在过去几年中出现。关于免疫反击和病毒之间的界面的发现已经提供了重要的理解,而临床试验已经显示了潜在的结果。
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Oncolytic Virotherapy: An Advanced Microbial Approach for the Management of Cancer.

Destruction of the tumor (cancerous) cells may be caused by live viruses, which have replicative ability and replicate selectively in tumor cells, known as oncolytic virotherapy. In comparison of conservative cancer therapy, tumor-selective replicating viruses have more advantages. These viruses have introduced new methodologies for the human cancer treatment. Numerous strategies are used in development of virotherapeutics. Virotherapy is not unusual concept, but modern advances in technology of genetic modification of oncolytic viruses have improved the ability of targeting tumor cells more specifically, it triggered the development of novel ammunition to fight cancer. An effective virotherapeutic approach with oncolytic viruses exhibits the feasibility and safety under clinical approach. New strategies are being explored to overcome basic obstacles and challenges in virotherapy. Administration of oncolytic viruses, logically, will successfully augment new treatments against many kinds of tumors. Some encouraging antitumor responses shown by combination therapy are provoking strong immunity against established cancer. Chief developments in oncolytic virotherapy have seen in past several years. Significant understandings have been provided by findings on the interface among immune comebacks and viruses, whereas potential results have shown in clinical trials.

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来源期刊
Critical Reviews in Eukaryotic Gene Expression
Critical Reviews in Eukaryotic Gene Expression 生物-生物工程与应用微生物
CiteScore
2.70
自引率
0.00%
发文量
67
审稿时长
1 months
期刊介绍: Critical ReviewsTM in Eukaryotic Gene Expression presents timely concepts and experimental approaches that are contributing to rapid advances in our mechanistic understanding of gene regulation, organization, and structure within the contexts of biological control and the diagnosis/treatment of disease. The journal provides in-depth critical reviews, on well-defined topics of immediate interest, written by recognized specialists in the field. Extensive literature citations provide a comprehensive information resource. Reviews are developed from an historical perspective and suggest directions that can be anticipated. Strengths as well as limitations of methodologies and experimental strategies are considered.
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