大规模伤亡事件二次分流算法的验证:基于模拟的研究英文版。

Die Anaesthesiologie Pub Date : 2023-12-01 Epub Date: 2023-10-12 DOI:10.1007/s00101-023-01292-2
Axel R Heller, Tobias Neidel, Patrick J Klotz, André Solarek, Barbara Kowalzik, Kathleen Juncken, Christan Kleber
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引用次数: 0

摘要

背景:在发生大规模伤亡事件(MCI)的情况下,当患者被从事件现场运送出来时,与情况相关的医疗资源短缺并没有结束。因此,需要在接收医院进行初步分流。在第一步中,本研究的目的是创建一个具有定义的分诊类别的参考患者小插曲集。这允许在第二步中对MCI情况的分诊算法的诊断质量进行计算机辅助评估。方法:由最初的6名和后来的36名分诊专家将总共250个在实践中验证的病例小插曲纳入多阶段评估过程。这种对所有小插曲的算法独立专家评估是分析以下分诊算法诊断质量的黄金标准:曼彻斯特分诊系统(MTS模块MCI)、紧急情况严重程度指数(ESI)、柏林分诊算法(BER)、院前算法PRIOR和mSTaRT,以及联邦民事保护和灾害援助办公室(BBK)与约旦哈希姆王国医院内约旦-德国项目算法(JorD)和院前分流算法(PETRA)合作的两个项目算法。每个患者的小插曲都通过所有指定的算法进行了计算机化分诊,以获得比较测试质量的结果。结果:在最初的250个小插曲中,210个患者小插曲的分诊参考数据库独立于算法进行了验证。这些形成了对所分析的分类算法进行比较的黄金标准。T1分诊类别患者的院内检测灵敏度范围为1.0(BER、JorD、PRIOR)至0.57(MCI模块MTS)。特异性范围从0.99(MTS和PETRA)到0.67(PRIOR)。考虑到Youden指数,BER(0.89)和JorD(0.88)在检测T1分类患者方面的总体表现最好。最有可能使用PRIOR进行过度试验,而使用MTS的MCI模块进行欠试验。在决定T1类之前,算法需要以下步骤数作为中位数和四分位间距(IQR):ESI 1(1-2)、Jord1(1-4)、PRIOR 3(2-4)、BER 3(2-6)、mSTaRT 3(3-5)、MTS 4(4-5)和PETRA 6(6-8)。对于T2和T3类别,直到决策的步骤数和算法的测试质量是正相关的。结论:在本研究中,证明了基于临床前算法的初级分诊结果向基于临床算法的次级分诊结果的可转移性。柏林分诊算法为二次分诊提供了最高的诊断质量,其次是约旦-德国项目的医院算法,然而,在做出决定之前,这也需要最多的算法步骤。
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Validation of secondary triage algorithms for mass casualty incidents : A simulation-based study-English version.

Background: In the event of a mass casualty incident (MCI), the situation-related shortage of medical resources does not end when the patients are transported from the scene of the incident. Consequently, an initial triage is required in the receiving hospitals. In the first step, the aim of this study was to create a reference patient vignette set with defined triage categories. This allowed a computer-aided evaluation of the diagnostic quality of triage algorithms for MCI situations in the second step.

Methods: A total of 250 case vignettes validated in practice were entered into a multistage evaluation process by initially 6 and later 36 triage experts. This algorithm-independent expert evaluation of all vignettes-served as the gold standard for analyzing the diagnostic quality of the following triage algorithms: Manchester triage system (MTS module MCI), emergency severity index (ESI), Berlin triage algorithm (BER), the prehospital algorithms PRIOR and mSTaRT, and two project algorithms from a cooperation between the Federal Office of Civil Protection and Disaster Assistance (BBK) and the Hashemite Kingdom of Jordan-intrahospital Jordanian-German project algorithm (JorD) and prehospital triage algorithm (PETRA). Each patient vignette underwent computerized triage through all specified algorithms to obtain comparative test quality outcomes.

Results: Of the original 250 vignettes, a triage reference database of 210 patient vignettes was validated independently of the algorithms. These formed the gold standard for comparison of the triage algorithms analyzed. Sensitivities for intrahospital detection of patients in triage category T1 ranged from 1.0 (BER, JorD, PRIOR) to 0.57 (MCI module MTS). Specificities ranged from 0.99 (MTS and PETRA) to 0.67 (PRIOR). Considering Youden's index, BER (0.89) and JorD (0.88) had the best overall performance for detecting patients in triage category T1. Overtriage was most likely with PRIOR, and undertriage with the MCI module of MTS. Up to a decision for category T1, the algorithms require the following numbers of steps given as the median and interquartile range (IQR): ESI 1 (1-2), JorD 1 (1-4), PRIOR 3 (2-4), BER 3 (2-6), mSTaRT 3 (3-5), MTS 4 (4-5) and PETRA 6 (6-8). For the T2 and T3 categories the number of steps until a decision and the test quality of the algorithms are positively interrelated.

Conclusion: In the present study, transferability of preclinical algorithm-based primary triage results to clinical algorithm-based secondary triage results was demonstrated. The highest diagnostic quality for secondary triage was provided by the Berlin triage algorithm, followed by the Jordanian-German project algorithm for hospitals, which, however, also require the most algorithm steps until a decision.

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