Etamsylate负载氧化魔芋葡甘聚糖-ε-聚赖氨酸可注射水凝胶,用于快速止血和伤口愈合。

IF 6.1 3区 医学 Q1 MATERIALS SCIENCE, BIOMATERIALS Journal of Materials Chemistry B Pub Date : 2023-10-13 DOI:10.1039/D3TB01904G
Shuo Xu, Jun You, Shaorong Yan, Luting Zhu and Xiaochen Wu
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引用次数: 0

摘要

无法控制的出血是导致死亡的关键因素。因此,开发能够快速止血的止血敷料至关重要。水凝胶具有可注射性、自我修复能力和粘附性,具有作为有效止血敷料的巨大潜力。本文以氧化的魔芋葡甘聚糖和ε-聚赖氨酸为原料制备了复合水凝胶。在包埋止血药物依他磺酸盐后,制备了一种氧化魔芋葡甘聚糖/ε-聚赖氨酸/依他磺酸盐(OKGM/PL/E)复合水凝胶,该水凝胶具有良好的可注射性、自修复能力、组织粘附性、血液相容性和细胞相容性。OKGM/PL/E水凝胶证明了有效粘附红细胞和密封伤口的能力,能够快速控制出血。体内伤口愈合实验证实了OKGM/PL/E水凝胶的止血和伤口愈合功效,突出了其作为一种有价值的止血敷料的潜力。
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Etamsylate loaded oxidized Konjac glucomannan-ε-polylysine injectable hydrogels for rapid hemostasis and wound healing

Uncontrollable bleeding is a crucial factor that can lead to fatality. Therefore, the development of hemostatic dressings that enable rapid hemostasis is of utmost importance. Hydrogels with injectability, self-healing ability, and adhesiveness hold significant potential as effective hemostatic dressings. Herein, a composite hydrogel was fabricated by the oxidized Konjac glucomannan and ε-polylysine. After the encapsulation of a hemostatic drug, etamsylate, an oxidized Konjac glucomannan/ε-polylysine/etamsylate (OKGM/PL/E) composite hydrogel that possesses favorable properties including injectability, self-healing ability, tissue adhesiveness, hemocompatibility and cytocompatibility was fabricated. The OKGM/PL/E hydrogel demonstrated the ability to effectively adhere red blood cells and seal wounds, enabling rapid control of hemorrhaging. In vivo wound healing experiments confirmed the hemostatic and wound healing efficacy of the OKGM/PL/E hydrogel, highlighting its potential as a valuable hemostatic dressing.

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来源期刊
Journal of Materials Chemistry B
Journal of Materials Chemistry B MATERIALS SCIENCE, BIOMATERIALS-
CiteScore
11.50
自引率
4.30%
发文量
866
期刊介绍: Journal of Materials Chemistry A, B & C cover high quality studies across all fields of materials chemistry. The journals focus on those theoretical or experimental studies that report new understanding, applications, properties and synthesis of materials. Journal of Materials Chemistry A, B & C are separated by the intended application of the material studied. Broadly, applications in energy and sustainability are of interest to Journal of Materials Chemistry A, applications in biology and medicine are of interest to Journal of Materials Chemistry B, and applications in optical, magnetic and electronic devices are of interest to Journal of Materials Chemistry C.Journal of Materials Chemistry B is a Transformative Journal and Plan S compliant. Example topic areas within the scope of Journal of Materials Chemistry B are listed below. This list is neither exhaustive nor exclusive: Antifouling coatings Biocompatible materials Bioelectronics Bioimaging Biomimetics Biomineralisation Bionics Biosensors Diagnostics Drug delivery Gene delivery Immunobiology Nanomedicine Regenerative medicine & Tissue engineering Scaffolds Soft robotics Stem cells Therapeutic devices
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