屋尘螨过敏儿童皮下变应原特异性免疫治疗后不良反应的回顾性评价。

Northern clinics of Istanbul Pub Date : 2023-09-25 eCollection Date: 2023-01-01 DOI:10.14744/nci.2023.78871
Ugur Altas, Aysen Cetemen, Zeynep Meva Altas, Emre Akkelle, Mehmet Yasar Ozkars
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摘要

目的:尽管它被认为是一种有效和安全的治疗方法,但皮下免疫疗法(SCIT)可能会产生副作用。在我们的研究中,旨在评估儿童SCIT后的局部和全身反应,以及可能与这些反应相关的因素。方法:我们的研究纳入了138名患有哮喘和/或过敏性鼻炎的屋尘螨过敏患者,他们于2013年11月至2022年4月在儿科过敏和免疫学门诊接受了SCIT。从患者档案中分析SCIT后的社会形态、临床、实验室特征和不良反应的发展。结果:138例患者的中位年龄为9.0岁。男性占56.5%(n=78),女性占43.5%(n=60)。在这些患者中,55.1%(n=76)患有哮喘和过敏性鼻炎。我们诊所的所有患者共接受了7366次SCIT注射。观察到的不良反应总数为118例。50.7%的患者(n=70)在SCIT后出现至少一种不良反应。每次注射不良反应发生率为1.6%(局部:1.0%,大面积局部:0.1%,全身:0.5%);应注意儿童SCIT期间不良反应的发展。
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Retrospective evaluation of adverse reactions after subcutaneous allergen-specific immunotherapy in children with house dust mite allergy.

Objective: Although it is accepted as an effective and safe treatment way, side effects can be observed as a result of subcutaneous immunotherapy (SCIT). In our study, it was aimed to evaluate the local and systemic reactions in children after SCIT and the factors that may be associated with these reactions.

Methods: Our study included 138 house dust mite allergic patients with asthma and/or allergic rhinitis who underwent SCIT in the Pediatric Allergy and Immunology Outpatient Clinic between November 2013 and April 2022. Sociodemographic, clinical, laboratory features, and development of adverse reactions after SCIT were analyzed from patient files.

Results: The median age of 138 patients was 9.0 years. About 56.5% (n=78) were male, 43.5% (n=60) were female. Of the patients, 55.1% (n=76) had asthma and allergic rhinitis. A total of 7366 SCIT injections were administered to all patients in our clinic. The total number of observed adverse reaction was 118. 50.7% of the patients (n=70) experienced at least one adverse reaction after SCIT. The rate of development of adverse reactions per injection was 1.6% (local: 1.0%, large local: 0.1%, systemic: 0.5%).

Conclusion: Although serious systemic reactions and death were not observed in our patients; care should be taken in terms of the development of adverse reactions during SCIT in children.

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