Laser-Ablated Tin Dioxide Nanoparticle Synthesis for Enhanced Biomedical Applications

Abstract

In the current study, SnO₂ nanoparticles were fabricated using laser ablation in water and characterized using ultraviolet-visible (UV-vis) spectroscopy, Fourier transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM), and X-ray diffraction (XRD). The XRD results showed that the fabricated nanoparticles had a tetragonal crystal structure. TEM micrographs revealed that the nanoparticles were spherical, with average sizes ranging from 10 to 50 nm, depending on the laser energy used. The band gap energy of the SnO₂ nanoparticles was found to increase with decreasing particle size. The antibacterial activity of the SnO₂ nanoparticles was tested against Staphylococcus aureus and Escherichia coli, and the results showed that the nanoparticles were more effective against S. aureus. In addition, the anticancer activity of the SnO₂ nanoparticles was tested against the lung cancer cell line A549 cells, and the findings suggest that the nanoparticles can act as an anti-proliferative agent against A549 cells. This study reveals that SnO₂ nanoparticles that are synthesized by laser ablation in water could be a future strategy for other biomedical applications such as antifungal, antiviral, and immune modulators.