Michael Dare Asemoloye, Tunde Sheriffdeen Bello, Peter Olusakin Oladoye, Muideen Remilekun Gbadamosi, Segun Oladiran Babarinde, Gboyega Ebenezer Adebami, Olumayowa Mary Olowe, Marta Elisabetta Eleonora Temporiti, Wolfgang Wanek, Mario Andrea Marchisio
{"title":"工程酵母和木质纤维素生物材料:为生物炼制和全球生物经济塑造新的维度。","authors":"Michael Dare Asemoloye, Tunde Sheriffdeen Bello, Peter Olusakin Oladoye, Muideen Remilekun Gbadamosi, Segun Oladiran Babarinde, Gboyega Ebenezer Adebami, Olumayowa Mary Olowe, Marta Elisabetta Eleonora Temporiti, Wolfgang Wanek, Mario Andrea Marchisio","doi":"10.1080/21655979.2023.2269328","DOIUrl":null,"url":null,"abstract":"<p><p>The next milestone of synthetic biology research relies on the development of customized microbes for specific industrial purposes. Metabolic pathways of an organism, for example, depict its chemical repertoire and its genetic makeup. If genes controlling such pathways can be identified, scientists can decide to enhance or rewrite them for different purposes depending on the organism and the desired metabolites. The lignocellulosic biorefinery has achieved good progress over the past few years with potential impact on global bioeconomy. This principle aims to produce different bio-based products like biochemical(s) or biofuel(s) from plant biomass under microbial actions. Meanwhile, yeasts have proven very useful for different biotechnological applications. Hence, their potentials in genetic/metabolic engineering can be fully explored for lignocellulosic biorefineries. For instance, the secretion of enzymes above the natural limit (aided by genetic engineering) would speed-up the down-line processes in lignocellulosic biorefineries and the cost. Thus, the next milestone would greatly require the development of synthetic yeasts with much more efficient metabolic capacities to achieve basic requirements for particular biorefinery. This review gave comprehensive overview of lignocellulosic biomaterials and their importance in bioeconomy. Many researchers have demonstrated the engineering of several ligninolytic enzymes in heterologous yeast hosts. However, there are still many factors needing to be well understood like the secretion time, titter value, thermal stability, pH tolerance, and reactivity of the recombinant enzymes. Here, we give a detailed account of the potentials of engineered yeasts being discussed, as well as the constraints associated with their development and applications.</p>","PeriodicalId":8919,"journal":{"name":"Bioengineered","volume":null,"pages":null},"PeriodicalIF":4.2000,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/48/25/KBIE_14_2269328.PMC10586088.pdf","citationCount":"0","resultStr":"{\"title\":\"Engineered yeasts and lignocellulosic biomaterials: shaping a new dimension for biorefinery and global bioeconomy.\",\"authors\":\"Michael Dare Asemoloye, Tunde Sheriffdeen Bello, Peter Olusakin Oladoye, Muideen Remilekun Gbadamosi, Segun Oladiran Babarinde, Gboyega Ebenezer Adebami, Olumayowa Mary Olowe, Marta Elisabetta Eleonora Temporiti, Wolfgang Wanek, Mario Andrea Marchisio\",\"doi\":\"10.1080/21655979.2023.2269328\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The next milestone of synthetic biology research relies on the development of customized microbes for specific industrial purposes. 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Thus, the next milestone would greatly require the development of synthetic yeasts with much more efficient metabolic capacities to achieve basic requirements for particular biorefinery. This review gave comprehensive overview of lignocellulosic biomaterials and their importance in bioeconomy. Many researchers have demonstrated the engineering of several ligninolytic enzymes in heterologous yeast hosts. However, there are still many factors needing to be well understood like the secretion time, titter value, thermal stability, pH tolerance, and reactivity of the recombinant enzymes. 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Engineered yeasts and lignocellulosic biomaterials: shaping a new dimension for biorefinery and global bioeconomy.
The next milestone of synthetic biology research relies on the development of customized microbes for specific industrial purposes. Metabolic pathways of an organism, for example, depict its chemical repertoire and its genetic makeup. If genes controlling such pathways can be identified, scientists can decide to enhance or rewrite them for different purposes depending on the organism and the desired metabolites. The lignocellulosic biorefinery has achieved good progress over the past few years with potential impact on global bioeconomy. This principle aims to produce different bio-based products like biochemical(s) or biofuel(s) from plant biomass under microbial actions. Meanwhile, yeasts have proven very useful for different biotechnological applications. Hence, their potentials in genetic/metabolic engineering can be fully explored for lignocellulosic biorefineries. For instance, the secretion of enzymes above the natural limit (aided by genetic engineering) would speed-up the down-line processes in lignocellulosic biorefineries and the cost. Thus, the next milestone would greatly require the development of synthetic yeasts with much more efficient metabolic capacities to achieve basic requirements for particular biorefinery. This review gave comprehensive overview of lignocellulosic biomaterials and their importance in bioeconomy. Many researchers have demonstrated the engineering of several ligninolytic enzymes in heterologous yeast hosts. However, there are still many factors needing to be well understood like the secretion time, titter value, thermal stability, pH tolerance, and reactivity of the recombinant enzymes. Here, we give a detailed account of the potentials of engineered yeasts being discussed, as well as the constraints associated with their development and applications.
期刊介绍:
Bioengineered provides a platform for publishing high quality research on any aspect of genetic engineering which involves the generation of recombinant strains (both prokaryote and eukaryote) for beneficial applications in food, medicine, industry, environment and bio-defense.