工程酵母和木质纤维素生物材料:为生物炼制和全球生物经济塑造新的维度。

IF 4.2 4区 生物学 Q2 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Bioengineered Pub Date : 2023-12-01 Epub Date: 2023-10-18 DOI:10.1080/21655979.2023.2269328
Michael Dare Asemoloye, Tunde Sheriffdeen Bello, Peter Olusakin Oladoye, Muideen Remilekun Gbadamosi, Segun Oladiran Babarinde, Gboyega Ebenezer Adebami, Olumayowa Mary Olowe, Marta Elisabetta Eleonora Temporiti, Wolfgang Wanek, Mario Andrea Marchisio
{"title":"工程酵母和木质纤维素生物材料:为生物炼制和全球生物经济塑造新的维度。","authors":"Michael Dare Asemoloye,&nbsp;Tunde Sheriffdeen Bello,&nbsp;Peter Olusakin Oladoye,&nbsp;Muideen Remilekun Gbadamosi,&nbsp;Segun Oladiran Babarinde,&nbsp;Gboyega Ebenezer Adebami,&nbsp;Olumayowa Mary Olowe,&nbsp;Marta Elisabetta Eleonora Temporiti,&nbsp;Wolfgang Wanek,&nbsp;Mario Andrea Marchisio","doi":"10.1080/21655979.2023.2269328","DOIUrl":null,"url":null,"abstract":"<p><p>The next milestone of synthetic biology research relies on the development of customized microbes for specific industrial purposes. Metabolic pathways of an organism, for example, depict its chemical repertoire and its genetic makeup. If genes controlling such pathways can be identified, scientists can decide to enhance or rewrite them for different purposes depending on the organism and the desired metabolites. The lignocellulosic biorefinery has achieved good progress over the past few years with potential impact on global bioeconomy. This principle aims to produce different bio-based products like biochemical(s) or biofuel(s) from plant biomass under microbial actions. Meanwhile, yeasts have proven very useful for different biotechnological applications. Hence, their potentials in genetic/metabolic engineering can be fully explored for lignocellulosic biorefineries. For instance, the secretion of enzymes above the natural limit (aided by genetic engineering) would speed-up the down-line processes in lignocellulosic biorefineries and the cost. Thus, the next milestone would greatly require the development of synthetic yeasts with much more efficient metabolic capacities to achieve basic requirements for particular biorefinery. This review gave comprehensive overview of lignocellulosic biomaterials and their importance in bioeconomy. Many researchers have demonstrated the engineering of several ligninolytic enzymes in heterologous yeast hosts. However, there are still many factors needing to be well understood like the secretion time, titter value, thermal stability, pH tolerance, and reactivity of the recombinant enzymes. Here, we give a detailed account of the potentials of engineered yeasts being discussed, as well as the constraints associated with their development and applications.</p>","PeriodicalId":8919,"journal":{"name":"Bioengineered","volume":null,"pages":null},"PeriodicalIF":4.2000,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/48/25/KBIE_14_2269328.PMC10586088.pdf","citationCount":"0","resultStr":"{\"title\":\"Engineered yeasts and lignocellulosic biomaterials: shaping a new dimension for biorefinery and global bioeconomy.\",\"authors\":\"Michael Dare Asemoloye,&nbsp;Tunde Sheriffdeen Bello,&nbsp;Peter Olusakin Oladoye,&nbsp;Muideen Remilekun Gbadamosi,&nbsp;Segun Oladiran Babarinde,&nbsp;Gboyega Ebenezer Adebami,&nbsp;Olumayowa Mary Olowe,&nbsp;Marta Elisabetta Eleonora Temporiti,&nbsp;Wolfgang Wanek,&nbsp;Mario Andrea Marchisio\",\"doi\":\"10.1080/21655979.2023.2269328\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The next milestone of synthetic biology research relies on the development of customized microbes for specific industrial purposes. Metabolic pathways of an organism, for example, depict its chemical repertoire and its genetic makeup. If genes controlling such pathways can be identified, scientists can decide to enhance or rewrite them for different purposes depending on the organism and the desired metabolites. The lignocellulosic biorefinery has achieved good progress over the past few years with potential impact on global bioeconomy. This principle aims to produce different bio-based products like biochemical(s) or biofuel(s) from plant biomass under microbial actions. Meanwhile, yeasts have proven very useful for different biotechnological applications. Hence, their potentials in genetic/metabolic engineering can be fully explored for lignocellulosic biorefineries. For instance, the secretion of enzymes above the natural limit (aided by genetic engineering) would speed-up the down-line processes in lignocellulosic biorefineries and the cost. Thus, the next milestone would greatly require the development of synthetic yeasts with much more efficient metabolic capacities to achieve basic requirements for particular biorefinery. This review gave comprehensive overview of lignocellulosic biomaterials and their importance in bioeconomy. Many researchers have demonstrated the engineering of several ligninolytic enzymes in heterologous yeast hosts. However, there are still many factors needing to be well understood like the secretion time, titter value, thermal stability, pH tolerance, and reactivity of the recombinant enzymes. Here, we give a detailed account of the potentials of engineered yeasts being discussed, as well as the constraints associated with their development and applications.</p>\",\"PeriodicalId\":8919,\"journal\":{\"name\":\"Bioengineered\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.2000,\"publicationDate\":\"2023-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/48/25/KBIE_14_2269328.PMC10586088.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Bioengineered\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.1080/21655979.2023.2269328\",\"RegionNum\":4,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2023/10/18 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"BIOTECHNOLOGY & APPLIED MICROBIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bioengineered","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1080/21655979.2023.2269328","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/10/18 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"BIOTECHNOLOGY & APPLIED MICROBIOLOGY","Score":null,"Total":0}
引用次数: 0

摘要

合成生物学研究的下一个里程碑依赖于为特定工业目的开发定制微生物。例如,一个生物体的代谢途径描述了它的化学库和基因组成。如果控制这些途径的基因能够被识别,科学家可以决定根据生物体和所需的代谢产物,为不同的目的增强或重写它们。木质纤维素生物炼制在过去几年中取得了良好的进展,对全球生物经济产生了潜在的影响。该原理旨在通过微生物作用从植物生物质中生产不同的生物基产品,如生物化学或生物燃料。同时,酵母已被证明在不同的生物技术应用中非常有用。因此,它们在遗传/代谢工程中的潜力可以在木质纤维素生物炼制中得到充分探索。例如,超过天然极限的酶的分泌(在基因工程的帮助下)将加快木质纤维素生物精炼厂的下游过程和成本。因此,下一个里程碑将极大地需要开发具有更有效代谢能力的合成酵母,以实现特定生物炼制的基本要求。综述了木质纤维素生物材料及其在生物经济中的重要性。许多研究人员已经证明了几种木质素分解酶在异源酵母宿主中的工程化。然而,仍有许多因素需要充分了解,如分泌时间、滴度、热稳定性、pH耐受性和重组酶的反应性。在这里,我们详细介绍了正在讨论的工程酵母的潜力,以及与它们的开发和应用相关的限制因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

摘要图片

摘要图片

摘要图片

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
Engineered yeasts and lignocellulosic biomaterials: shaping a new dimension for biorefinery and global bioeconomy.

The next milestone of synthetic biology research relies on the development of customized microbes for specific industrial purposes. Metabolic pathways of an organism, for example, depict its chemical repertoire and its genetic makeup. If genes controlling such pathways can be identified, scientists can decide to enhance or rewrite them for different purposes depending on the organism and the desired metabolites. The lignocellulosic biorefinery has achieved good progress over the past few years with potential impact on global bioeconomy. This principle aims to produce different bio-based products like biochemical(s) or biofuel(s) from plant biomass under microbial actions. Meanwhile, yeasts have proven very useful for different biotechnological applications. Hence, their potentials in genetic/metabolic engineering can be fully explored for lignocellulosic biorefineries. For instance, the secretion of enzymes above the natural limit (aided by genetic engineering) would speed-up the down-line processes in lignocellulosic biorefineries and the cost. Thus, the next milestone would greatly require the development of synthetic yeasts with much more efficient metabolic capacities to achieve basic requirements for particular biorefinery. This review gave comprehensive overview of lignocellulosic biomaterials and their importance in bioeconomy. Many researchers have demonstrated the engineering of several ligninolytic enzymes in heterologous yeast hosts. However, there are still many factors needing to be well understood like the secretion time, titter value, thermal stability, pH tolerance, and reactivity of the recombinant enzymes. Here, we give a detailed account of the potentials of engineered yeasts being discussed, as well as the constraints associated with their development and applications.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Bioengineered
Bioengineered BIOTECHNOLOGY & APPLIED MICROBIOLOGY-
CiteScore
8.20
自引率
28.60%
发文量
1114
审稿时长
17 weeks
期刊介绍: Bioengineered provides a platform for publishing high quality research on any aspect of genetic engineering which involves the generation of recombinant strains (both prokaryote and eukaryote) for beneficial applications in food, medicine, industry, environment and bio-defense.
期刊最新文献
Retracted article: Protective effects of ulinastatin on rats with acute lung injury induced by lipopolysaccharide. Retracted article: MicroRNA-4521 targets hepatoma up-regulated protein (HURP) to inhibit the malignant progression of breast cancer. Retracted article: MYCN contributes to the sensitization of acute myelogenous leukemia cells to cisplatin by targeting SRY-box transcription factor 4. Retracted article: Knockdown of long non-coding RNA AGAP2-AS1 suppresses the proliferation and metastasis of glioma by targeting microRNA-497-5p. Retracted article: Functional analysis of ceRNA network of lncRNA TSIX/miR-34a-5p/RBP2 in acute myocardial infarction based on GEO database.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1