Tyler L Coye, Mehmet A Suludere, Gu Eon Kang, P Andrew Crisologo, Matthew Malone, Lee C Rogers, Lawrence A Lavery
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The ESR/albumin and CRP/albumin ratios cut-points were >17.84 and >1.83, respectively. ESR/albumin and CRP/albumin ratios had similar diagnostic parameters: AUC (0.71, 0.71), sensitivity (70.0%, 57.0%), specificity (62.0%, 75.0%), positive predictive value (67.0%, 71.0%) and negative predictive value (66.0% and 71.0%). In contrast diagnostic efficiency of CRP and ESR were AUC 0.71 and 0.71, sensitivity (45.6%, 71.2%), specificity (85.5%, 60.7%), positive predictive value (70.0%, 65.9%) and negative predictive value (59.5%, 66.4%), respectively. When comparing area under the curves, the results showed that ESR/albumin was not significantly different to ESR alone (Delong test p<sub>vs ESR</sub> >0.1). Similarly, CRP/albumin was not significantly different to CRP alone (Delong test p<sub>vs CRP</sub> >0.1). In conclusion, ESR/albumin and CRP/albumin ratios provided comparable results as using ESR and CRP alone.</p>","PeriodicalId":23864,"journal":{"name":"Wound Repair and Regeneration","volume":null,"pages":null},"PeriodicalIF":3.8000,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The infected diabetes-related foot: Comparison of erythrocyte sedementation rate/albumin and C-reactive protein/albumin ratios with erythrocyte sedimentation rate and C-reactive protein to differentiate bone and soft tissue infections.\",\"authors\":\"Tyler L Coye, Mehmet A Suludere, Gu Eon Kang, P Andrew Crisologo, Matthew Malone, Lee C Rogers, Lawrence A Lavery\",\"doi\":\"10.1111/wrr.13121\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The objective of this study was to evaluate the effectiveness of C-reactive protein (CRP)/albumin, erythrocyte sedimentation rate (ESR)/albumin ratio, ESR, CRP and albumin to differentiate bone and soft tissue infection in persons with diabetes. We retrospectively evaluated 242 individuals admitted to hospital with diabetes-related foot infections (DFI). We categorised DFI cases as either bone (OM) or soft tissue infection based on bone culture and/or histology. We evaluated the diagnostic accuracy of CRP, ESR, albumin, CRP/albumin and ESR/albumin as biomarkers to diagnose OM in persons with diabetes. The median age was 53 years (74% male). There were 224 diabetes-related patients of which 125 had been diagnosed with osteomyelitis. The ESR/albumin and CRP/albumin ratios cut-points were >17.84 and >1.83, respectively. ESR/albumin and CRP/albumin ratios had similar diagnostic parameters: AUC (0.71, 0.71), sensitivity (70.0%, 57.0%), specificity (62.0%, 75.0%), positive predictive value (67.0%, 71.0%) and negative predictive value (66.0% and 71.0%). In contrast diagnostic efficiency of CRP and ESR were AUC 0.71 and 0.71, sensitivity (45.6%, 71.2%), specificity (85.5%, 60.7%), positive predictive value (70.0%, 65.9%) and negative predictive value (59.5%, 66.4%), respectively. When comparing area under the curves, the results showed that ESR/albumin was not significantly different to ESR alone (Delong test p<sub>vs ESR</sub> >0.1). Similarly, CRP/albumin was not significantly different to CRP alone (Delong test p<sub>vs CRP</sub> >0.1). 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引用次数: 0
摘要
本研究的目的是评估CRP/白蛋白、ESR/白蛋白比值、ESR、CRP和白蛋白在糖尿病患者骨和软组织感染鉴别中的有效性。我们回顾性评估了242名因糖尿病相关足部感染(DFI)入院的患者。我们根据骨培养和/或组织学将DFI病例分为骨(OM)或软组织感染(STI)。我们评估了CRP、ESR、白蛋白、CRP/白蛋白和ESR/白蛋白作为诊断糖尿病患者OM的生物标志物的诊断准确性。中位年龄为53岁 年龄(74%为男性)。共有224名糖尿病相关患者,其中125人被诊断为骨髓炎。ESR/白蛋白和CRP/白蛋白比值的分界点为> 17.84和> 1.83。ESR/白蛋白和CRP/白蛋白比值具有相似的诊断参数:AUC(0.71,0.71)、敏感性(70.0%,57.0%)、特异性(62.0%,75.0%)、阳性预测值(67.0%,71.0%)和阴性预测值(66.0%和71.0%),阳性预测值(70.0%,65.9%)和阴性预测值(59.5%,66.4%)。当比较曲线下面积时,结果显示ESR/白蛋白与单独的ESR没有显著差异(德隆检验p vs ESR> 0.1)。同样,CRP/白蛋白与单独的CRP没有显著差异(Delong检验p vs CRP> 0.1)。总之,ESR/白蛋白和CRP/白蛋白比率提供了与单独使用ESR和CRP相当的结果。这篇文章受版权保护。保留所有权利。
The infected diabetes-related foot: Comparison of erythrocyte sedementation rate/albumin and C-reactive protein/albumin ratios with erythrocyte sedimentation rate and C-reactive protein to differentiate bone and soft tissue infections.
The objective of this study was to evaluate the effectiveness of C-reactive protein (CRP)/albumin, erythrocyte sedimentation rate (ESR)/albumin ratio, ESR, CRP and albumin to differentiate bone and soft tissue infection in persons with diabetes. We retrospectively evaluated 242 individuals admitted to hospital with diabetes-related foot infections (DFI). We categorised DFI cases as either bone (OM) or soft tissue infection based on bone culture and/or histology. We evaluated the diagnostic accuracy of CRP, ESR, albumin, CRP/albumin and ESR/albumin as biomarkers to diagnose OM in persons with diabetes. The median age was 53 years (74% male). There were 224 diabetes-related patients of which 125 had been diagnosed with osteomyelitis. The ESR/albumin and CRP/albumin ratios cut-points were >17.84 and >1.83, respectively. ESR/albumin and CRP/albumin ratios had similar diagnostic parameters: AUC (0.71, 0.71), sensitivity (70.0%, 57.0%), specificity (62.0%, 75.0%), positive predictive value (67.0%, 71.0%) and negative predictive value (66.0% and 71.0%). In contrast diagnostic efficiency of CRP and ESR were AUC 0.71 and 0.71, sensitivity (45.6%, 71.2%), specificity (85.5%, 60.7%), positive predictive value (70.0%, 65.9%) and negative predictive value (59.5%, 66.4%), respectively. When comparing area under the curves, the results showed that ESR/albumin was not significantly different to ESR alone (Delong test pvs ESR >0.1). Similarly, CRP/albumin was not significantly different to CRP alone (Delong test pvs CRP >0.1). In conclusion, ESR/albumin and CRP/albumin ratios provided comparable results as using ESR and CRP alone.
期刊介绍:
Wound Repair and Regeneration provides extensive international coverage of cellular and molecular biology, connective tissue, and biological mediator studies in the field of tissue repair and regeneration and serves a diverse audience of surgeons, plastic surgeons, dermatologists, biochemists, cell biologists, and others.
Wound Repair and Regeneration is the official journal of The Wound Healing Society, The European Tissue Repair Society, The Japanese Society for Wound Healing, and The Australian Wound Management Association.