橄榄油酚类化合物对线粒体的生物学效应

IF 2.6 Q3 ONCOLOGY Molecular and Cellular Oncology Pub Date : 2022-03-20 DOI:10.1080/23723556.2022.2044263

Mercedes Blanco-Benítez, Ana Calderón-Fernández, Saray Canales-Cortés, Eva Alegre-Cortés, E. Uribe-Carretero, Marta Paredes-Barquero, Alberto Giménez-Bejarano, Gema Duque González, P. Gomez-Suaga, J. Ortega-Vidal, S. Salido, J. Altarejos, G. Martínez-Chacón, M. Niso-Santano, J. M. Fuentes, R. González-Polo, S. M. Yakhine-Diop

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引用次数: 6

摘要

摘要：从橄榄油中提取的酚类化合物具有对抗癌症、神经退行性疾病和代谢性疾病的有益健康特性。因此，它们对线粒体功能的影响存在差异，导致氧化能力、线粒体呼吸和能量需求的变化。这篇综述的重点是油尿蛋白的多功能作用，油尿蛋白是一种强效抗氧化剂，可调节AMPK/SIRT1/mTOR通路，调节自噬/线粒体自噬并维持代谢稳态。

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Biological effects of olive oil phenolic compounds on mitochondria

ABSTRACT Phenolic compounds derived from olive oil have beneficial health properties against cancer, neurodegenerative, and metabolic diseases. Therefore, there are discrepancies in their impact on mitochondrial function that result in changes in oxidative capacity, mitochondrial respiration, and energetic demands. This review focuses on the versatile role of oleuropein, a potent antioxidant that regulates the AMPK/SIRT1/mTOR pathway to modulate autophagy/mitophagy and maintain metabolic homeostasis.

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来源期刊

Molecular and Cellular Oncology Biochemistry, Genetics and Molecular Biology-Cancer Research

CiteScore

3.20

自引率

0.00%

发文量

期刊介绍： For a long time, solid neoplasms have been viewed as relatively homogeneous entities composed for the most part of malignant cells. It is now clear that tumors are highly heterogeneous structures that evolve in the context of intimate interactions between cancer cells and endothelial, stromal as well as immune cells. During the past few years, experimental and clinical oncologists have witnessed several conceptual transitions of this type. Molecular and Cellular Oncology (MCO) emerges within this conceptual framework as a high-profile forum for the publication of fundamental, translational and clinical research on cancer. The scope of MCO is broad. Submissions dealing with all aspects of oncogenesis, tumor progression and response to therapy will be welcome, irrespective of whether they focus on solid or hematological neoplasms. MCO has gathered leading scientists with expertise in multiple areas of cancer research and other fields of investigation to constitute a large, interdisciplinary, Editorial Board that will ensure the quality of articles accepted for publication. MCO will publish Original Research Articles, Brief Reports, Reviews, Short Reviews, Commentaries, Author Views (auto-commentaries) and Meeting Reports dealing with all aspects of cancer research.