MnII和FeII大环配合物的Ct-DNA结合及抗菌研究

IF 1.7 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Journal of Inclusion Phenomena and Macrocyclic Chemistry Pub Date : 2022-06-03 DOI:10.1007/s10847-022-01150-5
Anuj Kumar, Vinod Kumar Vashistha, Dipak Kumar Das, Ram K. Gupta, Ghulam Yasin
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引用次数: 2

摘要

如何设计有效的大环配合物来改变核酸及其理解仍存在争议。为了研究脱氧核糖核酸(DNA)与mn5配合物的相互作用,合成了两个大环配合物A (MnII)和B (FeII),并利用多种分析技术对其进行了表征。利用电子吸收、荧光和电化学方法检测这两种复合物与小牛胸腺dna (ct-DNA)的结合能力。在循环伏安分析中发现,在ct-DNA存在下,两种配合物的阳极峰电流(ipa)和阴极峰电流(ipc)显著降低,这也支持了光谱结果与ct-DNA的相互作用。光谱研究清楚地表明配合物A对ct-DNA的结合亲和力高于配合物B。此外,这两种配合物也被发现是潜在的抗菌剂。
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Ct-DNA binding and antimicrobial studies of MnII and FeII macrocyclic complexes

The designing of efficient macrocyclic complexes for the alteration in nucleic acids and understanding is still in debate. Herein, to study the deoxyribonucleic acid (DNA) interaction with MN5-complexes, two macrocyclic complexes, A (MnII) and B (FeII), have been synthesized and characterized using multiple analytical techniques. The electronic absorption, fluorescence, and electrochemical methods were utilized to examine the binding ability of both complexes with calf thymus-DNA (ct-DNA). The spectral results were found to be in good agreement with the interaction of both complexes with ct-DNA, as also supported by the remarkable decrease in both anodic peak current (ipa) and cathodic peak current (ipc) during cyclic voltammetric analysis in the presence of ct-DNA. The spectral investigations clearly indicated the higher binding affinity of complex A as compared to complex B towards ct-DNA. Additionally, both complexes were also found to be potential antibacterial agents.

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来源期刊
Journal of Inclusion Phenomena and Macrocyclic Chemistry
Journal of Inclusion Phenomena and Macrocyclic Chemistry Agricultural and Biological Sciences-Food Science
CiteScore
4.10
自引率
8.70%
发文量
54
期刊介绍: The Journal of Inclusion Phenomena and Macrocyclic Chemistry is the premier interdisciplinary publication reporting on original research into all aspects of host-guest systems. Examples of specific areas of interest are: the preparation and characterization of new hosts and new host-guest systems, especially those involving macrocyclic ligands; crystallographic, spectroscopic, thermodynamic and theoretical studies; applications in chromatography and inclusion polymerization; enzyme modelling; molecular recognition and catalysis by inclusion compounds; intercalates in biological and non-biological systems, cyclodextrin complexes and their applications in the agriculture, flavoring, food and pharmaceutical industries; synthesis, characterization and applications of zeolites. The journal publishes primarily reports of original research and preliminary communications, provided the latter represent a significant advance in the understanding of inclusion science. Critical reviews dealing with recent advances in the field are a periodic feature of the journal.
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