肿瘤细胞分泌组对抗和促肿瘤药物的反应

Onco Pub Date : 2021-10-31 DOI:10.3390/onco1020009
Shengzhi Liu, Xun Sun, Ke-xin Li, Chien-Chi Lin, S. Na, Bai-Yan Li, H. Yokota
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引用次数: 8

摘要

肿瘤细胞不仅通过其细胞体内的因子,而且通过其产生和分泌的分泌组来调节其进程。虽然它们的分泌组显著改变肿瘤细胞本身的命运,但它们也调节周围细胞的生长,包括伴癌细胞和非癌细胞。肿瘤细胞分泌组由不同的分子组成,这些分子大多被报道为肿瘤促进分子。此外,它们的促肿瘤能力通过化疗药物的应用而增强。然而,多种新出现的证据表明,肿瘤细胞分泌组在响应旁分泌和内分泌信号时可能具有肿瘤抑制作用。本文综述了肿瘤促进和肿瘤抑制分泌组,重点介绍了细胞内和细胞外区域的多任务蛋白。我们描述了控制肿瘤细胞分泌组性质的致瘤性信号,并讨论了诱导肿瘤抑制蛋白质组作为癌症治疗的新选择的可能性。我们评估了从一种独特类型的肿瘤修饰细胞(称为“诱导肿瘤抑制细胞”(iTSCs))中产生肿瘤抑制蛋白质组的反直觉程序。
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Tumor Cell Secretomes in Response to Anti- and Pro-Tumorigenic Agents
Tumor cells regulate their progression not only by the factors within their cell bodies but also by the secretome they produce and secrete. While their secretome significantly alters the fate of tumor cells themselves, they also regulate the growth of surrounding cells including both companion cancer and non-cancer cells. Tumor cell secretome consists of varying molecules that have been reported mostly tumor-promotive. Furthermore, their pro-tumor capability is enhanced by the application of chemotherapeutic agents. However, multiple lines of emerging evidence suggest that the tumor cell secretome can be tumor-suppressive in response to paracrine and endocrine signaling. This review introduces both tumor-promotive and tumor-suppressive secretomes, focusing on multi-tasking proteins in the intracellular and extracellular domains. We describe tumorigenic signaling that governs the nature of the tumor cell secretome and discuss the possibility of inducing tumor-suppressive proteomes as a novel option for cancer treatment. We evaluated the counterintuitive procedure to generate tumor-suppressive proteomes from a unique type of tumor-modifying cells, which are named “induced tumor-suppressing cells” (iTSCs).
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