{"title":"英文版本:原发性高血压的表型画像作为一种工具，以提高其诊断效率和进展的男性多态变异的心营养因子-1基因","authors":"M. O. Matokhniuk, I. Pashkova, V. Zhebel","doi":"10.31718/mep.2020.24.5-6.04","DOIUrl":null,"url":null,"abstract":"Chronic heart failure (CHF) is one of the prognostic complications of essential hypertension (EH), which is the most common non-communicable disease in the world. The aim of the study is to improve the effectiveness of diagnosis of EH progression based on cluster analysis, which is based on anthropometric, laboratory and systemic and intracardiac hemodynamics in men 40-60 years. The study included 50 men with asymptomatic EH aged 50.62 ± 0.73 years and 50 men with EH complicated by CHF aged 51.86 ± 0.81 years. All participants underwent standard cardio-graphic examinations, the plasma concentration of cardiotrophin-1 (CT-1) in the blood was determined by enzyme-linked immunosorbent assay (ELISA) and rs8046707 of the CT-1 gene in venous blood samples using the PLR method. The phenotypic portrait of the patient was distinguished by cluster analysis.","PeriodicalId":32911,"journal":{"name":"Problemi ekologiyi ta meditsini","volume":"1 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2020-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"ENGLISH VERSION:PHENOTYPIC PORTRAIT OF ESSENTIAL HYPERTENSION AS A TOOL TO INCREASE THE EFFICIENCY OF ITS DIAGNOSIS AND PROGRESSION IN MEN WITH POLYMORPHIC VARIANTS OF THE CARDIOTROPHIN-1 GENE\",\"authors\":\"M. O. Matokhniuk, I. Pashkova, V. Zhebel\",\"doi\":\"10.31718/mep.2020.24.5-6.04\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Chronic heart failure (CHF) is one of the prognostic complications of essential hypertension (EH), which is the most common non-communicable disease in the world. The aim of the study is to improve the effectiveness of diagnosis of EH progression based on cluster analysis, which is based on anthropometric, laboratory and systemic and intracardiac hemodynamics in men 40-60 years. The study included 50 men with asymptomatic EH aged 50.62 ± 0.73 years and 50 men with EH complicated by CHF aged 51.86 ± 0.81 years. All participants underwent standard cardio-graphic examinations, the plasma concentration of cardiotrophin-1 (CT-1) in the blood was determined by enzyme-linked immunosorbent assay (ELISA) and rs8046707 of the CT-1 gene in venous blood samples using the PLR method. The phenotypic portrait of the patient was distinguished by cluster analysis.\",\"PeriodicalId\":32911,\"journal\":{\"name\":\"Problemi ekologiyi ta meditsini\",\"volume\":\"1 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2020-12-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Problemi ekologiyi ta meditsini\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.31718/mep.2020.24.5-6.04\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Problemi ekologiyi ta meditsini","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.31718/mep.2020.24.5-6.04","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
ENGLISH VERSION:PHENOTYPIC PORTRAIT OF ESSENTIAL HYPERTENSION AS A TOOL TO INCREASE THE EFFICIENCY OF ITS DIAGNOSIS AND PROGRESSION IN MEN WITH POLYMORPHIC VARIANTS OF THE CARDIOTROPHIN-1 GENE
Chronic heart failure (CHF) is one of the prognostic complications of essential hypertension (EH), which is the most common non-communicable disease in the world. The aim of the study is to improve the effectiveness of diagnosis of EH progression based on cluster analysis, which is based on anthropometric, laboratory and systemic and intracardiac hemodynamics in men 40-60 years. The study included 50 men with asymptomatic EH aged 50.62 ± 0.73 years and 50 men with EH complicated by CHF aged 51.86 ± 0.81 years. All participants underwent standard cardio-graphic examinations, the plasma concentration of cardiotrophin-1 (CT-1) in the blood was determined by enzyme-linked immunosorbent assay (ELISA) and rs8046707 of the CT-1 gene in venous blood samples using the PLR method. The phenotypic portrait of the patient was distinguished by cluster analysis.
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