疱疹病毒在阿尔茨海默病中的作用:目前的证据和未来的方向

NeuroImmune pharmacology and therapeutics Pub Date : 2023-07-10 eCollection Date: 2023-09-01 DOI:10.1515/nipt-2023-0011
Stacey L Piotrowski, Allison Tucker, Steven Jacobson
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引用次数: 0

摘要

摘要阿尔茨海默病(AD)是痴呆症最常见的病因。虽然病理特征,如细胞外β淀粉样蛋白斑块,在受影响的个体中有很好的特征,但导致斑块形成和最终认知能力下降的发病机制尚不清楚。最近,几十年前的“传染性假说”死灰复燃,引起了人们对微生物在AD中可能发挥的潜在作用的越来越多的关注。在这一理论中,人们认为病毒等病原体可能是β淀粉样蛋白聚集的种子,最终导致斑块。对传染性假说的兴趣也促使人们进一步研究可能在AD进展中发挥作用的病毒感染的其他特征,如神经炎症、潜伏期和病毒DNA整合。尽管最近发表了一系列这方面的研究,其中疱疹病毒特别令人感兴趣,但病原体在AD中的作用仍然存在争议。在这篇综述中,总结了迄今为止对疱疹病毒在AD中可能作用的见解。还讨论了疱疹病毒在AD和痴呆症研究中的挑战和潜在的未来方向。
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The elusive role of herpesviruses in Alzheimer's disease: current evidence and future directions.

Alzheimer's disease (AD) is the most common cause of dementia. While pathologic hallmarks, such as extracellular beta-amyloid plaques, are well-characterized in affected individuals, the pathogenesis that causes plaque formation and eventual cognitive decline is not well understood. A recent resurgence of the decades-old "infectious hypothesis" has garnered increased attention on the potential role that microbes may play in AD. In this theory, it is thought that pathogens such as viruses may act as seeds for beta-amyloid aggregation, ultimately leading to plaques. Interest in the infectious hypothesis has also spurred further investigation into additional characteristics of viral infection that may play a role in AD progression, such as neuroinflammation, latency, and viral DNA integration. While a flurry of research in this area has been recently published, with herpesviruses being of particular interest, the role of pathogens in AD remains controversial. In this review, the insights gained thus far into the possible role of herpesviruses in AD are summarized. The challenges and potential future directions of herpesvirus research in AD and dementia are also discussed.

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