{"title":"叔n -苯基cf3 -亚氨基丙基醇的加氢卤化反应","authors":"R.S. Shulgin, O.G. Volostnykh, A.V. Stepanov, I.A. Ushakov, O.A. Shemyakina","doi":"10.1016/j.jfluchem.2023.110173","DOIUrl":null,"url":null,"abstract":"<div><p>A facile approach towards 4-halo-5,5-alkyl/aryl-<em>N</em>-phenyl-2-(trifluoromethyl)-2,5-dihydrofuran-2-amines by the reaction of readily available tertiary <em>N</em>-phenyl CF<sub>3</sub>-iminopropargylic alcohols with hydrohalic acids (HCl, HBr, HI) was developed. The obtained 4-halo-2,5-dihydrofurans were shown to readily undergo the reactions demonstrating their potential utility in the synthesis of various CF<sub>3</sub>-containing compounds.</p></div>","PeriodicalId":357,"journal":{"name":"Journal of Fluorine Chemistry","volume":null,"pages":null},"PeriodicalIF":1.7000,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Hydrohalogenation of tertiary N-phenyl CF3-iminopropargylic alcohols\",\"authors\":\"R.S. Shulgin, O.G. Volostnykh, A.V. Stepanov, I.A. Ushakov, O.A. Shemyakina\",\"doi\":\"10.1016/j.jfluchem.2023.110173\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>A facile approach towards 4-halo-5,5-alkyl/aryl-<em>N</em>-phenyl-2-(trifluoromethyl)-2,5-dihydrofuran-2-amines by the reaction of readily available tertiary <em>N</em>-phenyl CF<sub>3</sub>-iminopropargylic alcohols with hydrohalic acids (HCl, HBr, HI) was developed. The obtained 4-halo-2,5-dihydrofurans were shown to readily undergo the reactions demonstrating their potential utility in the synthesis of various CF<sub>3</sub>-containing compounds.</p></div>\",\"PeriodicalId\":357,\"journal\":{\"name\":\"Journal of Fluorine Chemistry\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.7000,\"publicationDate\":\"2023-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Fluorine Chemistry\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S002211392300088X\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, INORGANIC & NUCLEAR\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Fluorine Chemistry","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S002211392300088X","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, INORGANIC & NUCLEAR","Score":null,"Total":0}
Hydrohalogenation of tertiary N-phenyl CF3-iminopropargylic alcohols
A facile approach towards 4-halo-5,5-alkyl/aryl-N-phenyl-2-(trifluoromethyl)-2,5-dihydrofuran-2-amines by the reaction of readily available tertiary N-phenyl CF3-iminopropargylic alcohols with hydrohalic acids (HCl, HBr, HI) was developed. The obtained 4-halo-2,5-dihydrofurans were shown to readily undergo the reactions demonstrating their potential utility in the synthesis of various CF3-containing compounds.
期刊介绍：
The Journal of Fluorine Chemistry contains reviews, original papers and short communications. The journal covers all aspects of pure and applied research on the chemistry as well as on the applications of fluorine, and of compounds or materials where fluorine exercises significant effects. This can include all chemistry research areas (inorganic, organic, organometallic, macromolecular and physical chemistry) but also includes papers on biological/biochemical related aspects of Fluorine chemistry as well as medicinal, agrochemical and pharmacological research. The Journal of Fluorine Chemistry also publishes environmental and industrial papers dealing with aspects of Fluorine chemistry on energy and material sciences. Preparative and physico-chemical investigations as well as theoretical, structural and mechanistic aspects are covered. The Journal, however, does not accept work of purely routine nature.
For reviews and special issues on particular topics of fluorine chemistry or from selected symposia, please contact the Regional Editors for further details.
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