{"title":"Nrf2信号在调节疼痛和炎症中的作用","authors":"","doi":"10.20455/ros.2023.n807","DOIUrl":null,"url":null,"abstract":"The nuclear factor E2-related factor 2 (Nrf2) is best known for being the master transcriptional regulator of antioxidant genes. In addition, Nrf2 also regulates anti-inflammatory gene expression. Recent studies have discovered a critical function for Nrf2 signaling in modulating pain as well as in mediating the action of some commonly used non-steroidal anti-inflammatory and analgesic drugs (NSAIDs). This Cutting-Edge Research Highlights discusses these latest novel findings and proposes future research directions.","PeriodicalId":91793,"journal":{"name":"Reactive oxygen species (Apex, N.C.)","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2023-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Nrf2 Signaling in Modulating Pain and Inflammation\",\"authors\":\"\",\"doi\":\"10.20455/ros.2023.n807\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The nuclear factor E2-related factor 2 (Nrf2) is best known for being the master transcriptional regulator of antioxidant genes. In addition, Nrf2 also regulates anti-inflammatory gene expression. Recent studies have discovered a critical function for Nrf2 signaling in modulating pain as well as in mediating the action of some commonly used non-steroidal anti-inflammatory and analgesic drugs (NSAIDs). This Cutting-Edge Research Highlights discusses these latest novel findings and proposes future research directions.\",\"PeriodicalId\":91793,\"journal\":{\"name\":\"Reactive oxygen species (Apex, N.C.)\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-06-05\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Reactive oxygen species (Apex, N.C.)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.20455/ros.2023.n807\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Reactive oxygen species (Apex, N.C.)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.20455/ros.2023.n807","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Nrf2 Signaling in Modulating Pain and Inflammation
The nuclear factor E2-related factor 2 (Nrf2) is best known for being the master transcriptional regulator of antioxidant genes. In addition, Nrf2 also regulates anti-inflammatory gene expression. Recent studies have discovered a critical function for Nrf2 signaling in modulating pain as well as in mediating the action of some commonly used non-steroidal anti-inflammatory and analgesic drugs (NSAIDs). This Cutting-Edge Research Highlights discusses these latest novel findings and proposes future research directions.