A Review of NEMO Protein and its Relationship with Genetic Diseases

NF-κB essential modulator (NEMO) syndrome is an immunodeficiency disease. NF-κB proteins, which regulate the expression of genes that moderate important physiological processes, are called regulatory of cell homeostasis. NEMO is a protein in the IKK inhibitor complex that many organ systems normally do not grow. Cells (as well as organ and tissues) do not grow proteins they express proteins. The disease occurs due to mutation in the IKBKG gene. The IKBKG gene, located in the Xq28 chromosomal region or located in the X chromosome. The disease indicates an impairment of NF-κB activation and the initial treatment of NEMO is very difficult. About 70-80% of patients have similar DNA rearrangements. Epilepsy is observed in about 50% of patients with these disorders. Therefore, there is little information about the NEMO disease and more research is needed to further examine the syndrome.