亚洲人群中FTO多态性与2型糖尿病之间的关系:一项荟萃分析

IF 0.8 Q4 GENETICS & HEREDITY Meta Gene Pub Date : 2021-12-01 DOI:10.1016/j.mgene.2021.100958
Phung Thanh Huong, Cuc Thi Thu Nguyen, Vu Thi Nhung
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引用次数: 6

摘要

了解糖尿病的发病机制和危险因素是控制糖尿病的重要条件,其中遗传因素起着重要作用。据报道,FTO基因的几个变异是肥胖的易感性因素。在不同的亚洲人群中对FTO基因的各种变异进行了大量研究,但关于FTO基因与2型糖尿病(T2D)的关系的研究结果并不一致。本研究的目的是进行系统回顾和荟萃分析,以提供有关亚洲少数民族FTO基因多态性与T2D风险之间关系的最新和全面的证据。方法系统查阅PubMed数据库和Cochrane图书馆的文献,筛选符合条件的研究进行汇总分析。对于每个遗传多态性,在等位基因模型下估计每个研究的优势比及其95%置信区间。根据研究之间的异质性,使用随机效应模型或固定效应模型估计合并优势比。此外,还按地理区域进行了亚组分析。结果共纳入40项研究,81727名受试者。汇总分析结果显示,FTO基因的4个snp位点(rs9939609、rs8050136、rs3751812和rs7193144)与亚洲人群T2D易感性显著相关,其中rs3751812和rs7193144在meta分析中首次被报道。不同地理区域的证据强度存在差异。结论FTO基因的某些变异可用于识别亚洲人群中发生T2D的高危个体。
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The association between FTO polymorphisms and type 2 diabetes in Asian populations: A meta-analysis

Background

An important condition for the management of diabetes mellitus is thorough understandings of its pathogenesis and risk factors, of which genetic factors play essential roles. Several variants of the FTO gene were reported as an obesity susceptibility factor. There have been a number of studies conducted in different Asian populations on various variants of the FTO gene with inconsistent results on the association with type 2 diabetes (T2D). The purpose of this study is to undertake a systematic review and meta-analysis to provide updated and comprehensive evidence regarding the associations between FTO gene polymorphisms and T2D risk in the Asian ethnic communities.

Methods

A systematic literature research of PubMed database and Cochrane Library was performed to identify eligible studies for pooled analyses. For each genetic polymorphism, odds ratios and their 95% confidence intervals were estimated under allelic model for each individual study. Pooled odds ratios were estimated using a random-effects model or a fixed-effect model depending on the heterogeneity among studies. Further, subgroup analyses by geographic region was also performed.

Results

Totally 40 studies with 81,727 subjects were included for analyses. The pooled analyses showed that four SNPs of the FTO gene (rs9939609, rs8050136, rs3751812 and rs7193144) were significantly associated with susceptibility to T2D in Asian populations, of which, the rs3751812 and rs7193144 were reported for the first time in a meta-analysis. The evidence strength varied among different geographic regions.

Conclusions

The results supported that certain variants of the FTO gene could be used to identify individuals at high risk of developing T2D in Asians populations.

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来源期刊
Meta Gene
Meta Gene Biochemistry, Genetics and Molecular Biology-Genetics
CiteScore
1.10
自引率
0.00%
发文量
20
期刊介绍: Meta Gene publishes meta-analysis, polymorphism and population study papers that are relevant to both human and non-human species. Examples include but are not limited to: (Relevant to human specimens): 1Meta-Analysis Papers - statistical reviews of the published literature of human genetic variation (typically linked to medical conditionals and/or congenital diseases) 2Genome Wide Association Studies (GWAS) - examination of large patient cohorts to identify common genetic factors that influence health and disease 3Human Genetics Papers - original studies describing new data on genetic variation in smaller patient populations 4Genetic Case Reports - short communications describing novel and in formative genetic mutations or chromosomal aberrations (e.g., probands) in very small demographic groups (e.g., family or unique ethnic group). (Relevant to non-human specimens): 1Small Genome Papers - Analysis of genetic variation in organelle genomes (e.g., mitochondrial DNA) 2Microbiota Papers - Analysis of microbiological variation through analysis of DNA sequencing in different biological environments 3Ecological Diversity Papers - Geographical distribution of genetic diversity of zoological or botanical species.
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