Laboratory derangements and clinical picture of Covid-19 in pediatric age group: A retrospective study

Abstract Aim: To assess the clinical presentation and laboratory derangements of pediatric covid-19 patients admitted to the tertiary care hospital. Methodology: The present retrospective study was started after the approval of the Institutional Ethics Committee. Clinical (Sp02, final diagnosis and outcome) and biochemical parameters (Complete Blood Count, Liver Function Test, Renal Function Test, Lactate De-Hydrogenase, D-dimer, C-Reactive Protein, and Serum ferritin) of pediatric covid-19 patients were collected from Central Laboratory and Medical Record Department of our institution. Patient names were anonymized and data were analyzed. The results are expressed in percentages. Results: A total of 16 pediatric covid-19 patient details were identified and collected who were admitted during our study period. Out of 16 patients, 09 (56.2%) were female and the remaining 07 (43.7%) were male. Out of 16, 05 patients had mild covid, 07 were moderate and the remaining 04 suffered from severe covid-19 infection. The mean values of oxygen saturation, LDH, D-dimer, CRP, and Ferritin were 88%, 249.4U/L, 1140.9 ng/ml, 16.17 mg/dl, and 61.7 µg/L respectively. Mean values of 17.9 mg/dl and 0.4 mg/dl were recorded for blood urea and S.creatinine. Regarding liver function tests, mean values of 1.7mg/dl, 0.2mg/dl, 1.5mg/dl, 82.4 U/L, 55 U/L, 135.6 U/L respectively noted for total bilirubin, direct, indirect, SGOT, SGPT and ALP. Regarding patient outcomes, all the patients were covered and discharged from the hospital. Conclusion: The present study has found an increase in laboratory mean values of liver function tests but the mean values of C-Reactive protein, LDH, and d-dimer which are the acute inflammatory markers are highly disrupted compared to normal ranges.