胎盘增生谱:保守管理及其对未来生育的影响

Riwa A. Abbas, A. Nassar
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摘要

摘要植入性胎盘谱是妊娠期的一种并发症,对产妇健康构成极大的风险。从历史上看,子宫切除术是这种情况的治疗方式,但最近出现了一种更保守的治疗方法。这包括几种不同成功率和并发症的方法。期望管理在高达78%-80%的情况下是有效的。摘除方法与产后出血的高风险相关。一步保守手术的成功取决于胎盘侵袭的程度,而三P手术似乎是成功的,但需要跨学科的方法。辅助治疗方案可以根据个别病例进行定制,包括甲氨蝶呤注射、子宫断流术和宫腔镜切除残留的胎盘组织。保守治疗后的随访对于早期发现并发症至关重要,可以通过超声、多普勒检查和β-人绒毛膜促性腺激素水平趋势来进行。胎盘植入谱的保守管理可以保持未来的生育能力,但只能在有足够经验的医院进行,因为它具有很高的产妇并发症风险。在未来,应该进行更多的研究,以获得关于这一主题的明确指导方针。
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Placenta Accreta Spectrum: Conservative Management and Its Impact on Future Fertility
Abstract Placenta accreta spectrum is a complication of pregnancy, which poses a great risk on maternal health. Historically, hysterectomy was the modality of treatment of such condition, but an approach towards a more conservative management has been in the light recently. This includes several methods with varying rates of success and complications. Expectant management is effective in up to 78%–80% of the cases. The extirpative method is associated with a high risk of postpartum hemorrhage. The success of the one-step conservative procedure depends on the degree of placental invasion, and the triple-P procedure appears to be successful but requires and interdisciplinary approach. Adjuvant treatment options can be tailored according to individual cases, and these include methotrexate injection, uterine devascularization and hysteroscopic resection of retained placental tissues. Follow up after conservative management is crucial to detect complications early, and it can be done by ultrasound, Doppler examination, and trending β human chorionic gonadotropin levels. Conservative management of placenta accreta spectrum can preserve future fertility but should only be done in hospitals with enough experience as it carries a high risk of maternal complications. In the future, more research should be directed to achieve clear guidelines regarding this topic.
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