痴呆症预防研究诊所:一项纵向研究,调查新西兰奥特亚影响阿尔茨海默病发展的因素

IF 2.1 4区 综合性期刊 Q2 MULTIDISCIPLINARY SCIENCES Journal of the Royal Society of New Zealand Pub Date : 2022-08-24 eCollection Date: 2023-01-01 DOI:10.1080/03036758.2022.2098780
Lynette J Tippett, Erin E Cawston, Catherine A Morgan, Tracy R Melzer, Kiri L Brickell, Christina Ilse, Gary Cheung, Ian J Kirk, Reece P Roberts, Jane Govender, Leon Griner, Campbell Le Heron, Sarah Buchanan, Waiora Port, Makarena Dudley, Tim J Anderson, Joanna M Williams, Nicholas J Cutfield, John C Dalrymple-Alford, Phil Wood
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引用次数: 0

摘要

摘要Aotearoa新西兰的人口正在老龄化。随着预期寿命的延长,阿尔茨海默病(AD)和衰老相关疾病的患病率也在增加。这项多中心痴呆症预防研究诊所纵向研究旨在提高对奥特亚AD和痴呆症的理解,以制定延缓或预防痴呆进展的干预措施。这项多学科研究包括奥克兰、克赖斯特彻奇和达尼丁的研究诊所,涉及社区参与者,他们根据国际协议和最佳实践进行两年一次的调查:临床、神经心理学、神经影像学、生活方式评估、APOE基因分型、血液采集和处理。一个关键的研究目标是确定一种预测轻度认知障碍进展为AD的“生物标志物特征”。候选生物标志物包括:血液蛋白和微小RNA、遗传、神经影像学和神经心理学标志物、健康、文化、生活方式、感觉和心理社会因素。我们正在研究AD病理进展的一系列机制(如血脑屏障缺陷、实质铁过量、血管失调)。本文将概述痴呆症预防研究诊所研究的关键方面,提供数据收集的概述,以及迄今为止招募的266名参与者的摘要。诊所在全国的推广是一个优势;痴呆症预防研究诊所的核心是它的人。
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Dementia Prevention Research Clinic: a longitudinal study investigating factors influencing the development of Alzheimer's disease in Aotearoa, New Zealand.

Aotearoa New Zealand's population is ageing. Increasing life expectancy is accompanied by increases in prevalence of Alzheimer's Disease (AD) and ageing-related disorders. The multicentre Dementia Prevention Research Clinic longitudinal study aims to improve understanding of AD and dementia in Aotearoa, in order to develop interventions that delay or prevent progression to dementia. Comprising research clinics in Auckland, Christchurch and Dunedin, this multi-disciplinary study involves community participants who undergo biennial investigations informed by international protocols and best practice: clinical, neuropsychological, neuroimaging, lifestyle evaluations, APOE genotyping, blood collection and processing. A key research objective is to identify a 'biomarker signature' that predicts progression from mild cognitive impairment to AD. Candidate biomarkers include: blood proteins and microRNAs, genetic, neuroimaging and neuropsychological markers, health, cultural, lifestyle, sensory and psychosocial factors. We are examining a range of mechanisms underlying the progression of AD pathology (e.g. faulty blood-brain barrier, excess parenchymal iron, vascular dysregulation). This paper will outline key aspects of the Dementia Prevention Research Clinic's research, provide an overview of data collection, and a summary of 266 participants recruited to date. The national outreach of the clinics is a strength; the heart of the Dementia Prevention Research Clinics are its people.

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来源期刊
Journal of the Royal Society of New Zealand
Journal of the Royal Society of New Zealand 综合性期刊-综合性期刊
CiteScore
4.60
自引率
0.00%
发文量
74
审稿时长
3 months
期刊介绍: Aims: The Journal of the Royal Society of New Zealand reflects the role of Royal Society Te Aparangi in fostering research and debate across natural sciences, social sciences, and the humanities in New Zealand/Aotearoa and the surrounding Pacific. Research published in Journal of the Royal Society of New Zealand advances scientific knowledge, informs government policy, public awareness and broader society, and is read by researchers worldwide.
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