黄连素的脱氯甲基化制备小檗红——获得纯品的技巧

IF 0.9 Q4 CHEMISTRY, MULTIDISCIPLINARY Acta Chimica Slovaca Pub Date : 2020-04-01 DOI:10.2478/acs-2020-0014

V. Milata, Eva Holúbková

{"title":"黄连素的脱氯甲基化制备小檗红——获得纯品的技巧","authors":"V. Milata, Eva Holúbková","doi":"10.2478/acs-2020-0014","DOIUrl":null,"url":null,"abstract":"Abstract Berberine (1), as a compound with interesting biological activities, can be modified at various positions to obtain more potent substances. Modifications at position 9 are based on demethylation with simultaneous dechloration resulting in berberrubine. The most frequent process is thermal dechloromethylation and this work describes this method with detailed tricks to obtain almost pure product in high yield.","PeriodicalId":7088,"journal":{"name":"Acta Chimica Slovaca","volume":null,"pages":null},"PeriodicalIF":0.9000,"publicationDate":"2020-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":"{\"title\":\"Dechloromethylation of the berberine to berberrubine — tricks to obtain pure product\",\"authors\":\"V. Milata, Eva Holúbková\",\"doi\":\"10.2478/acs-2020-0014\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Abstract Berberine (1), as a compound with interesting biological activities, can be modified at various positions to obtain more potent substances. Modifications at position 9 are based on demethylation with simultaneous dechloration resulting in berberrubine. The most frequent process is thermal dechloromethylation and this work describes this method with detailed tricks to obtain almost pure product in high yield.\",\"PeriodicalId\":7088,\"journal\":{\"name\":\"Acta Chimica Slovaca\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.9000,\"publicationDate\":\"2020-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Acta Chimica Slovaca\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2478/acs-2020-0014\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta Chimica Slovaca","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2478/acs-2020-0014","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}

引用次数: 2

摘要

小檗碱(1)是一种具有有趣的生物活性的化合物，可以在不同的位置进行修饰，以获得更有效的物质。第9位的修饰是在去甲基化的基础上同时脱色，得到小檗碱。最常见的工艺是热脱氯甲基化，本文详细介绍了该方法以高收率获得几乎纯的产品的技巧。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

Dechloromethylation of the berberine to berberrubine — tricks to obtain pure product

Abstract Berberine (1), as a compound with interesting biological activities, can be modified at various positions to obtain more potent substances. Modifications at position 9 are based on demethylation with simultaneous dechloration resulting in berberrubine. The most frequent process is thermal dechloromethylation and this work describes this method with detailed tricks to obtain almost pure product in high yield.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Acta Chimica Slovaca CHEMISTRY, MULTIDISCIPLINARY-

自引率

12.50%

发文量