{"title":"SUVA/V和SUVA-V评价18F-FDG PET/CT动脉粥样硬化炎症的比较","authors":"Jeongryul Ryu, Shin Ae Han, Sangwon Han, Sunju Choi, Dae Hyuk Moon, Minyoung Oh","doi":"10.1007/s13139-023-00822-5","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to compare the clinical significance of two parameters, division of standardized uptake value (SUV) of target arterial activity by background venous blood pool activity (SUV<sub>A/V</sub>) and subtraction of background venous blood pool activity from SUV of target arterial activity (SUV<sub>A-V</sub>) of carotid arteries with atherosclerotic plaques using <sup>18</sup>F-fluorodeoxyglucose (FDG) positron emission tomography and computed tomography (PET/CT).</p><p><strong>Methods: </strong>Patients aged 50 years or more who were diagnosed with carotid artery stenosis of 50% or more with carotid Doppler ultrasonography and had torso <sup>18</sup>F-FDG PET/CT were enrolled retrospectively and classified patients who developed cerebrovascular events (CVEs) within 5 years after <sup>18</sup>F-FDG PET/CT scan as the active group and patients who did not experience the CVE within 5 years as an inactive group. We calculated SUV<sub>A/V</sub> and SUV<sub>A-V</sub> using measurements of SUV<sub>max</sub> of carotid arteries and mean SUV of superior vena cava (SVC).</p><p><strong>Results: </strong>SUV<sub>A-V</sub>, SUV<sub>A-V_high</sub>, and SUV<sub>A-V_low</sub> were significantly higher in the active group than in the inactive group, but neither SUV<sub>A/V</sub>, SUV<sub>A/V_high</sub>, nor SUV<sub>A/V_low</sub> showed significant differences between the active and inactive groups. The difference in rank between groups of SUV<sub>A/V_high</sub> and SUV<sub>A/V_low</sub> was greater than the difference in rank between groups of SUV<sub>A-V_high</sub> and SUV<sub>A-V_low</sub>. The CVE incidence differed between SUV<sub>A/V_high</sub> and SUV<sub>A/V_low</sub> of high carotid FDG uptake, but the CVE incidence did not differ between SUV<sub>A-V_high</sub> and SUV<sub>A-V_low</sub> of high carotid FDG uptake.</p><p><strong>Conclusion: </strong>SUV<sub>A-V</sub> may be a more rational solution than SUV<sub>A/V</sub> for evaluating atherosclerotic plaque inflammation on <sup>18</sup>F-FDG PET/CT.</p>","PeriodicalId":19384,"journal":{"name":"Nuclear Medicine and Molecular Imaging","volume":null,"pages":null},"PeriodicalIF":1.3000,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10796899/pdf/","citationCount":"0","resultStr":"{\"title\":\"Comparison of SUV<sub>A</sub><sub>/V</sub> and SUV<sub>A</sub><sub>-V</sub> for Evaluating Atherosclerotic Inflammation in <sup>18</sup>F-FDG PET/CT.\",\"authors\":\"Jeongryul Ryu, Shin Ae Han, Sangwon Han, Sunju Choi, Dae Hyuk Moon, Minyoung Oh\",\"doi\":\"10.1007/s13139-023-00822-5\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>This study aimed to compare the clinical significance of two parameters, division of standardized uptake value (SUV) of target arterial activity by background venous blood pool activity (SUV<sub>A/V</sub>) and subtraction of background venous blood pool activity from SUV of target arterial activity (SUV<sub>A-V</sub>) of carotid arteries with atherosclerotic plaques using <sup>18</sup>F-fluorodeoxyglucose (FDG) positron emission tomography and computed tomography (PET/CT).</p><p><strong>Methods: </strong>Patients aged 50 years or more who were diagnosed with carotid artery stenosis of 50% or more with carotid Doppler ultrasonography and had torso <sup>18</sup>F-FDG PET/CT were enrolled retrospectively and classified patients who developed cerebrovascular events (CVEs) within 5 years after <sup>18</sup>F-FDG PET/CT scan as the active group and patients who did not experience the CVE within 5 years as an inactive group. We calculated SUV<sub>A/V</sub> and SUV<sub>A-V</sub> using measurements of SUV<sub>max</sub> of carotid arteries and mean SUV of superior vena cava (SVC).</p><p><strong>Results: </strong>SUV<sub>A-V</sub>, SUV<sub>A-V_high</sub>, and SUV<sub>A-V_low</sub> were significantly higher in the active group than in the inactive group, but neither SUV<sub>A/V</sub>, SUV<sub>A/V_high</sub>, nor SUV<sub>A/V_low</sub> showed significant differences between the active and inactive groups. The difference in rank between groups of SUV<sub>A/V_high</sub> and SUV<sub>A/V_low</sub> was greater than the difference in rank between groups of SUV<sub>A-V_high</sub> and SUV<sub>A-V_low</sub>. The CVE incidence differed between SUV<sub>A/V_high</sub> and SUV<sub>A/V_low</sub> of high carotid FDG uptake, but the CVE incidence did not differ between SUV<sub>A-V_high</sub> and SUV<sub>A-V_low</sub> of high carotid FDG uptake.</p><p><strong>Conclusion: </strong>SUV<sub>A-V</sub> may be a more rational solution than SUV<sub>A/V</sub> for evaluating atherosclerotic plaque inflammation on <sup>18</sup>F-FDG PET/CT.</p>\",\"PeriodicalId\":19384,\"journal\":{\"name\":\"Nuclear Medicine and Molecular Imaging\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.3000,\"publicationDate\":\"2024-02-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10796899/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nuclear Medicine and Molecular Imaging\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1007/s13139-023-00822-5\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2023/9/5 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nuclear Medicine and Molecular Imaging","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/s13139-023-00822-5","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/9/5 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
Comparison of SUVA/V and SUVA-V for Evaluating Atherosclerotic Inflammation in 18F-FDG PET/CT.
Purpose: This study aimed to compare the clinical significance of two parameters, division of standardized uptake value (SUV) of target arterial activity by background venous blood pool activity (SUVA/V) and subtraction of background venous blood pool activity from SUV of target arterial activity (SUVA-V) of carotid arteries with atherosclerotic plaques using 18F-fluorodeoxyglucose (FDG) positron emission tomography and computed tomography (PET/CT).
Methods: Patients aged 50 years or more who were diagnosed with carotid artery stenosis of 50% or more with carotid Doppler ultrasonography and had torso 18F-FDG PET/CT were enrolled retrospectively and classified patients who developed cerebrovascular events (CVEs) within 5 years after 18F-FDG PET/CT scan as the active group and patients who did not experience the CVE within 5 years as an inactive group. We calculated SUVA/V and SUVA-V using measurements of SUVmax of carotid arteries and mean SUV of superior vena cava (SVC).
Results: SUVA-V, SUVA-V_high, and SUVA-V_low were significantly higher in the active group than in the inactive group, but neither SUVA/V, SUVA/V_high, nor SUVA/V_low showed significant differences between the active and inactive groups. The difference in rank between groups of SUVA/V_high and SUVA/V_low was greater than the difference in rank between groups of SUVA-V_high and SUVA-V_low. The CVE incidence differed between SUVA/V_high and SUVA/V_low of high carotid FDG uptake, but the CVE incidence did not differ between SUVA-V_high and SUVA-V_low of high carotid FDG uptake.
Conclusion: SUVA-V may be a more rational solution than SUVA/V for evaluating atherosclerotic plaque inflammation on 18F-FDG PET/CT.
期刊介绍:
Nuclear Medicine and Molecular Imaging (Nucl Med Mol Imaging) is an official journal of the Korean Society of Nuclear Medicine, which bimonthly publishes papers on February, April, June, August, October, and December about nuclear medicine and related sciences such as radiochemistry, radiopharmacy, dosimetry and pharmacokinetics / pharmacodynamics of radiopharmaceuticals, nuclear and molecular imaging analysis, nuclear and molecular imaging instrumentation, radiation biology and radionuclide therapy. The journal specially welcomes works of artificial intelligence applied to nuclear medicine. The journal will also welcome original works relating to molecular imaging research such as the development of molecular imaging probes, reporter imaging assays, imaging cell trafficking, imaging endo(exo)genous gene expression, and imaging signal transduction. Nucl Med Mol Imaging publishes the following types of papers: original articles, reviews, case reports, editorials, interesting images, and letters to the editor.
The Korean Society of Nuclear Medicine (KSNM)
KSNM is a scientific and professional organization founded in 1961 and a member of the Korean Academy of Medical Sciences of the Korean Medical Association which was established by The Medical Services Law. The aims of KSNM are the promotion of nuclear medicine and cooperation of each member. The business of KSNM includes holding academic meetings and symposia, the publication of journals and books, planning and research of promoting science and health, and training and qualification of nuclear medicine specialists.