肾移植的性别差异- 10年回顾性研究

L. Kováčiková, Ľ. Beňa, E. Lacková, Z. Žilinská, K. Graňák, P. Skálová, M. Vnučák, L. Laca, M. Mokáň, I. Dedinská
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引用次数: 1

摘要

摘要背景:慢性肾脏病是一个全球性的健康问题,影响着全球约1.95亿妇女。女性患慢性肾脏疾病的风险更大;因此,2018年世界肾脏日专门针对女性患者的肾脏疾病、治疗选择及其具体情况。材料和方法:我们回顾性分析了2005年至2015年期间斯洛伐克所有移植中心1457名肾移植患者的队列。考虑的参数是终末期肾病(ESRD)的病因,即性别差异下的移植结果。结果:在十年期间,共有557名女性接受了移植,而900名男性接受了移植。女性受者ESRD的主要原因是肾小管间质性肾炎(男性22.3%对女性32.1%,女性明显多于男性的ESRD的其他原因包括多囊肾病(男性11.6%对女性17.6%,p=0.0013)和系统性红斑狼疮(男性0.2%对女性2.3%,p=0.0001)。男性和女性在12个月、5年和10年的移植物和患者生存率方面没有显着差异。尽管透析时间相当,但女性受者等待肾移植的时间明显更长(男性32.9个月,女性39.4个月,p<0.0001)。结论:尽管在我们的研究中,男性和女性受者的患者和移植物存活率相当,但其他研究表明,性别和性别不匹配显著影响移植
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Gender Differences in Kidney Transplantation – 10-Year Retrospective Study
Abstract Background: Chronic kidney disease represents a world-wide health problem affecting approximately 195 million women around the world. Risk of development of chronic kidney disease is greater in women; therefore, the World Kidney Day 2018 was dedicated to kidney disease, treatment options, and its specifics in female patients. Materials and Methods: We retrospectively analysed a cohort of 1,457 patients after kidney transplantation from all transplant centres in Slovakia over a period of ten years from 2005 – 2015.The parameters taken into account were cause of end-stage renal disease (ESRD), outcome of transplantation in a context of differences between the genders. Results: During the ten-year period there were 557 transplanted women vs. 900 men. Among female recipient the dominant cause of ESRD was tubulointerstitial nephritis (males 22.3% vs. females 32.1%, p < 0.0001), other causes of ESRD where females were significantly more represented than men included polycystic kidney disease (males 11.6% vs. females 17.6%, p = 0.0013) and systemic lupus erythematosus (males 0.2% vs. females 2.3 %, p = 0.0001). There was no significant difference in 12-month, 5-year, and 10-year both graft and patient survival rates between men and women. Female recipients wait for kidney transplantation significantly longer in spite of comparable time spent on dialysis (males 32.9 months vs. females 39.4 months, p < 0.0001). Conclusion: Despite comparable patient and graft survival rates in male and female recipients in our study there are other studies showing that gender as well as gender mismatch significantly influence the outcomes of transplantation.
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来源期刊
自引率
0.00%
发文量
11
审稿时长
14 weeks
期刊介绍: Acta Medica Martiniana is a medical scientific journal, first published in print form in December 2001. It is a continuation of the journal / almanac Folia Medica Martiniana (1971 - 1996). The journal‘s owner is the Jessenius Faculty of Medicine, Comenius University, Slovakia. Dissemination of research results and scientific knowledge from all areas of medicine and nursing. Stimulation, facilitation and supporting of publication activity for the young medical research and clinical generation. The contributions of young novice authors (PhD students and post-doctorials) are particularly welcome. Acta Medica Martiniana is an open-access journal, with a periodicity of publishing three times per year (Apr/Aug/Dec). It covers a wide range of basic medical disciplines, such as anatomy, histology, biochemistry, human physiology, pharmacology, etc., as well as all clinical areas incl. preventive medicine, public health and nursing. Interdisciplinary and multidisciplinary manuscripts, including papers from all areas of biomedical research, are welcome.
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