Primary splenic non-Hodgkin lymphoma of diffuse large B cell type; a case report and review of the literature

Background

Primary splenic lymphoma (PSL) is rare anatomical subtype of non-Hodgkin lymphoma which primarily originated from and limited to the spleen without other sites invasion, with a 6 months interval before lymphoma appearance in other locations.

Case presentation

In the present report we described a case of a female patient aged 59 years old with pathologically confirmed PSL.

The patient was with a left upper quadrant abdominal pain since 3 month. Radiological evaluation revealed diffuse splenomegaly. The patient underwent splenectomy and the histopathological examination of the spleen revealed high-grade non-Hodgkin B-cell lymphoma.

Conclusions

It is important to put in consideration that PSL although a rare, but must be considered as a differential diagnosis, in a patient with splenomegaly and abdominal pain in absence of specific clinical findings.