利用苯并咪唑基ICT荧光团对异常蛋白聚集体的多色荧光

IF 1.7 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Journal of Inclusion Phenomena and Macrocyclic Chemistry Pub Date : 2021-06-04 DOI:10.1007/s10847-021-01085-3
Jusung An, Paramesh Jangili, Sungsu Lim, Yun Kyung Kim, Peter Verwilst, Jong Seung Kim
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引用次数: 6

摘要

阿尔茨海默病(AD)的病理起源仍然是未知的领域,尽管深入的研究。通过成像方法区分异常蛋白沉积,如β-淀粉样蛋白(a β)和(过度磷酸化的)tau蛋白,是支持研究导致AD病理的相互作用特征网络的重要工具。在这种情况下,多光谱荧光成像(MSFI)引起了人们的广泛关注,它能够仅用单个荧光团发射多色荧光信号来区分几种分析物。本研究开发了三种苯并咪唑衍生的荧光染料BZ1-BZ3。考察了探针在不同溶剂中的光物理性质和分子内电荷转移(ICT)特性。此外,苯并咪唑相关的极性灵敏度显示出多色行为,并使a β和tau聚集体之间微环境极性的微小差异可视化,从而导致不同的最大荧光发射波长。事实上,BZ2在最大荧光发射中表现出约30 nm的色移。所有这些观察结果为未来一代苯并咪唑衍生的基于ict的荧光探针的开发提供了潜力。
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Multichromatic fluorescence towards aberrant proteinaceous aggregates utilizing benzimidazole-based ICT fluorophores

The pathological origin of Alzheimer’s disease (AD) remains uncharted terrain, despite intensive investigation. Discriminating aberrant proteinaceous deposits, such as β-amyloid (Aβ) and (hyperphosphorylated) tau protein by imaging methods, is a vital tool to support investigations towards the network of interacting features that results in AD pathology. In this context, multispectral fluorescence imaging (MSFI) has drawn much attention enabling the distinction of several analytes with merely a single fluorophore emitting a multichromatic fluorescent signal. Herein, we developed three kinds of benzimidazole-derived fluorescent dyes, BZ1BZ3. The photophysical properties and intramolecular charge transfer (ICT) characteristics of the probes were evaluated in various solvents. Furthermore, a benzimidazole-associated polar-sensitivity displayed multichromatic behavior and enabled the visualization of minute differences in microenvironmental polarity between Aβ and tau aggregates, resulting in different maximal fluorescent emission wavelengths. Indeed, BZ2 demonstrated an approximately 30 nm bathochromic shift in maximal fluorescent emission. All these observations offer a potential for the development of a future generation of benzimidazole-derived ICT-based fluorescent probes.

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来源期刊
Journal of Inclusion Phenomena and Macrocyclic Chemistry
Journal of Inclusion Phenomena and Macrocyclic Chemistry Agricultural and Biological Sciences-Food Science
CiteScore
4.10
自引率
8.70%
发文量
54
期刊介绍: The Journal of Inclusion Phenomena and Macrocyclic Chemistry is the premier interdisciplinary publication reporting on original research into all aspects of host-guest systems. Examples of specific areas of interest are: the preparation and characterization of new hosts and new host-guest systems, especially those involving macrocyclic ligands; crystallographic, spectroscopic, thermodynamic and theoretical studies; applications in chromatography and inclusion polymerization; enzyme modelling; molecular recognition and catalysis by inclusion compounds; intercalates in biological and non-biological systems, cyclodextrin complexes and their applications in the agriculture, flavoring, food and pharmaceutical industries; synthesis, characterization and applications of zeolites. The journal publishes primarily reports of original research and preliminary communications, provided the latter represent a significant advance in the understanding of inclusion science. Critical reviews dealing with recent advances in the field are a periodic feature of the journal.
期刊最新文献
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