晚期慢性阻塞性肺疾病(COPD)患者的姑息治疗仍未得到充分利用

B. Hayward, D. Zappetti
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引用次数: 2

摘要

晚期慢性阻塞性肺病(COPD)患者痛苦症状负担重,生活质量差。姑息治疗策略可以解决这一问题;然而,在使用这些策略方面缺乏强有力的研究,包括全面评估晚期COPD患者姑息治疗服务使用情况的研究。这项研究考察了安大略省10年内晚期COPD患者的正式姑息治疗咨询、阿片类药物使用和长期氧疗(LTOT)的发生率。作者利用加拿大安大略省的卫生管理数据进行了一项基于人群的重复横断面研究。卫生管理数据库用于提供基本人口统计数据、医生提供的服务、65岁或65岁以上人群的处方药,以及2004年至2014年诊断为COPD患者的LTOT使用情况。晚期COPD患者是根据那些因COPD住院≥1次的患者和/或COPD患者使用LTOT来确定的。鉴于与经常使用姑息治疗服务的其他疾病组相比,COPD很难预测,1这项研究的独特之处在于,它没有限制对患者生命最后一年内的评估,而是限制在规定的研究期间使用任何姑息治疗服务。在这项研究中,约25%的晚期COPD患者曾因COPD住院,死亡率约为18%。这项研究表明,他们的晚期COPD患者群体使用正规姑息治疗服务的比例从2004年的5%增加到2014年的14%。他们发现,42%的同龄人在生命的最后6个月内接受了正式的姑息治疗服务。尽管这是一个重要的趋势,但它表明,考虑到COPD患者报告的高负担症状,以及将临终系列扩大到这一人群的潜力,正式的姑息治疗服务仍然没有得到充分利用。在晚期COPD患者中使用阿片类药物可以缓解严重的呼吸困难。2然而,许多研究表明,即使在COPD患者生命的最后一年,阿片类物质的使用率也相对较低,在各种国际研究中,这一比例从10%到25%不等。这归因于缺乏知识、教育和缺乏指导方针。在这项没有定义阿片类药物处方适应症的研究中,40%的晚期COPD患者在任何一年都有阿片类药处方。这比其他研究中发现的要高,但考虑到COPD患者呼吸困难等症状的高报告率,这再次表明利用不足。LTOT还可以缓解呼吸困难,可以被视为晚期COPD患者姑息治疗策略的一部分。这项研究发现,LTOT的使用率从每年约1%增加到研究最后一年的35%。同样,尽管这是一个重要的趋势,但它表明LTOT在缓解晚期COPD患者症状方面可能没有得到充分利用。总之,本研究为晚期COPD患者的姑息治疗利用提供了一个更全面的评估。尽管姑息治疗策略的使用有所增加,但这表明这些策略的利用不足,这可能有助于减轻晚期COPD患者的严重症状负担和痛苦。
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Palliative Care For Patients With Advanced Chronic Obstructive Pulmonary Disease (COPD) Remains Underutilized
P atients with advanced chronic obstructive pulmonary disease (COPD) have a high burden of distressing symptoms and poor quality of life. Palliative care strategies can address this; however, robust research in the use of these strategies is lacking, including studies to comprehensively assess the utilization of palliative care services in advanced COPD. This study examines the rates of formal palliative care consultation, opioid use, and long-term oxygen therapy (LTOT) for patients with advanced COPD in Ontario over a period of 10 years. The authors conducted a population-based repeated crosssectional study using health administrative data from Ontario, Canada. Health administrative databases were used to provide basic demographic data, services provided by physicians, a prescription medication for those 65 years of age or older, and the use of LTOT from 2004 to 2014, in patients with a diagnosis of COPD. Patients with advanced COPD were identified on the basis of those with ≥ 1 hospitalizations for COPD and/or the use of LTOT in those with COPD. Given that COPD is difficult to prognosticate compared with other disease groups that utilize palliative care services frequently,1 this study was unique in that it did not limit assessment of patients within their last year of life, but rather any palliative care service use during the defined study period. For this study, about 25% of patients with advanced COPD had a COPD-related hospitalization, with a mortality rate of around 18%. This study demonstrated that there was an increase in the use of formal palliative care services from 5% in 2004 to 14% in 2014 for their patient population with advanced COPD. They found that 42% of their cohort received formal palliative care services within the last 6 months of life. Although this is an important trend, it suggests that formal palliative care services are still underutilized, given the high burden of symptoms reported by patients with COPD, and the potential to expand end-of-life series to this population. Opioid use in patients with advanced COPD can alleviate severe dyspnea.2 However, numerous studies have shown relatively low use of opioids in patients with COPD even in the last year of their life, from 10% to 25% in various international studies. This has been attributed to lack of knowledge, education, and lack of guidelines. In this study, which did not define the indication for opioid prescription, 40% of patients with advanced COPD had a prescription for opioids in any given year. This is higher than has been found in other studies, but, again, it suggests underutilization, given the high reports of symptoms such as breathlessness in COPD patients. LTOT can also alleviate dyspnea and can be considered part of a palliative care strategy for patients with advanced COPD. This study found an increase in the rate of LTOT use of about 1% per year to 35% use in the final year of the study. Again, while this is an important trend, it suggests that there may be an underutilization of LTOT for symptom relief in patients with advanced COPD. In summary, this study provides a more comprehensive assessment of palliative care utilization for patients with advanced COPD. Although there has been an increase in the use of palliative care strategies, it suggests an underutilization of these strategies, which may help alleviate significant symptom burden and suffering for patients with advanced COPD.
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Clinical Pulmonary Medicine
Clinical Pulmonary Medicine Medicine-Critical Care and Intensive Care Medicine
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期刊介绍: Clinical Pulmonary Medicine provides a forum for the discussion of important new knowledge in the field of pulmonary medicine that is of interest and relevance to the practitioner. This goal is achieved through mini-reviews on focused sub-specialty topics in areas covered within the journal. These areas include: Obstructive Airways Disease; Respiratory Infections; Interstitial, Inflammatory, and Occupational Diseases; Clinical Practice Management; Critical Care/Respiratory Care; Colleagues in Respiratory Medicine; and Topics in Respiratory Medicine.
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