原发性先天性青光眼患儿泪液中内皮素-1水平的变化

L. Katargina, N. B. Сhesnokova, N. N. Arestova, A. A. Sorokin, T. Pavlenko, O. Beznos, O. A. Lisovskaja
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摘要

目的。目的分析原发性先天性青光眼(PCG)患儿泪液(TF)中内皮素-1 (ET-1)的水平,并探讨临床与实验室数据之间可能的相关性。材料和方法。我们检查了15名7个月至15岁的PCG儿童的23只眼睛和这些儿童的3只健康的眼睛。25眼同龄无青光眼儿童(身体健康,轻度远视和/或伴发斜视)作为对照。标准眼科检查补充了闪光视觉诱发皮质电位、总和节律性视网膜电图、眼轴长回声测量、视神经头光学相干断层扫描、TF中ET-1水平的酶免疫测定(ELISA)。结果。大多数PCG患儿(95.6%)TF中ET-1水平(平均9.69±3.80 pg/ml)高于健康儿童(4.65±2.02 pg/ml) (p < 0.001)。在患有PCG的健康儿童的眼睛中也检测到ET-1水平升高(高达8.90 pg/ml)。3 ~ 15岁PCG患儿ET-1平均水平显著高于(p< 0.05),低于发病期。我们的研究显示ET-1水平与PCG患儿视网膜神经纤维层变薄程度或AL之间没有相关性。结论。首次发现与健康儿童相比,PCG患儿TF中ET-1水平升高。ET-1在远晚期的PCG阶段较低,这可以解释为长期慢性眼组织缺氧耗尽了眼睛的保护储备。由于未发现TF中ET-1水平与PVG患儿的临床及功能数据有明显相关性,因此我们不能明确地将TF中ET-1水平作为衡量PCG缺血程度的指标。需要进一步的研究来获得可靠的相关性。
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Endothelin-1 level in the tear fluid of children with primary congenital glaucoma
Purpose. To analyze the level of endothelin-1 (ET-1) in the tear fluid (TF) of children with primary congenital glaucoma (PCG) and to detect possible correlations between the clinical and the laboratory data. Material and methods. We examined 23 eyes of 15 children with PCG aged between 7 months and 15 years and 3 healthy fellow eyes of these children. 25 eyes of children of same age without glaucoma (somatically healthy with mild hyperopia and/or concomitant strabismus) served as control. A standard ophthalmological examination was supplemented by the flash visual evoked cortical potential, a total and a rhythmic electroretinogram, axial length (AL) echobiometry of the eye, optical coherence tomography of the optic nerve head, enzyme immunoassay (ELISA) of ET-1 level in TF were given. Results. In most children with PCG (95.6 %), the TF level of ET-1 (mean 9.69 ± 3.80 pg/ml) was higher than that in healthy children (4.65 ± 2,02 pg/ml) (p < 0.001). Increased levels of ET-1 (up to 8.90 pg/ml) were also detected in healthy fellow eyes of children with PCG. The mean level of ET-1 in children with PCG aged 3 to 15 years was significantly higher (p< 0.05) lower than in the initial stage. Our study revealed no correlations between the ET-1 level and the degree of retinal nerve fiber layer thinning, or the AL in children with PCG. Conclusion. For the first time, an increased level of ET-1 in the TF in children with PCG was revealed as compared to healthy children. A lower value of ET-1 in the far advanced PCG stage as compared to the initial stage can be explained by long-term chronic eye tissue hypoxia depleting the protective reserves of the eye. Since no obvious correlation between ET-1 level in the TF and clinical and functional data of children with PVG has been found, we cannot definitely view the ET-1 level in the TF as a measure of ischemia degree in PCG. Further studies are needed to obtain reliable correlations.
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来源期刊
CiteScore
0.50
自引率
0.00%
发文量
107
审稿时长
16 weeks
期刊最新文献
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