三苯基锡(IV)氨基苯甲酸酯化合物的合成及其对恶性疟原虫的抗疟活性

IF 1.8 3区化学 Q3 CHEMISTRY, INORGANIC & NUCLEAR Main Group Metal Chemistry Pub Date : 2021-01-01 DOI:10.1515/mgmc-2021-0028

S. Hadi, Mona Dwi Fenska, N. Noviany, H. Satria, W. Simanjuntak, M. Naseer

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引用次数: 10

摘要

摘要本文报道了由氢氧化三苯基锡(IV)与2-、3-和4-氨基苯甲酸反应合成的几种三苯基锡(IV)氨基苯甲酸酯化合物的抗疟活性。用恶性疟原虫对化合物的抗疟活性进行了评价，结果表明，化合物的IC50与阳性对照氯喹(2×10−3 μg/mL)的IC50基本相同。结果还表明，疟原虫对合成的化合物不耐药，与氯喹相反。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Synthesis and antimalarial activity of some triphenyltin(IV) aminobenzoate compounds against Plasmodium falciparum

Abstract This paper presents antimalarial activity of several triphenyltin(IV) aminobenzoate compounds synthesized from the reaction of triphenyltin(IV) hydroxide with 2-, 3-, and 4-aminobenzoic acid. The activity of the compounds as anti-malaria agents was evaluated using Plasmodium falciparum, and demonstrated that the compounds have about the same IC50 with that of chloroquine (2×10−3 μg/mL) applied as the positive control. The result also showed that the Plasmodium is non-resistent to the compounds synthesized, which is the opposite to chloroquine.

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来源期刊

Main Group Metal Chemistry CHEMISTRY, INORGANIC & NUCLEAR-CHEMISTRY, ORGANIC

CiteScore

4.10

自引率

27.80%

发文量

审稿时长

4 weeks

期刊介绍： This journal is committed to the publication of short communications, original research, and review articles within the field of main group metal and semi-metal chemistry, Main Group Metal Chemistry is an open-access, peer-reviewed journal that publishes in ongoing way. Papers addressing the theoretical, spectroscopic, mechanistic and synthetic aspects of inorganic, coordination and organometallic main group metal and semi-metal compounds, including zinc, cadmium and mercury are welcome. The journal also publishes studies relating to environmental aspects of these metals, their toxicology, release pathways and fate. Articles on the applications of main group metal chemistry, including in the fields of polymer chemistry, agriculture, electronics and catalysis, are also accepted.