癫痫发作是曲马多中毒/停药的罕见表现,氟西汀是曲马多滥用治疗中潜在的抗渴求药物

Faiz Mohammed Kassim, Selamawit Alemayehu Tessema, Selamawit Darota Dojamo, Bethelhem Erkeno Wossoro
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引用次数: 0

摘要

曲马多是一种具有阿片类和单胺能作用的中枢镇痛药。曲马多通常用于治疗中度严重疼痛。然而,曲马多的非医疗使用以及曲马多中毒正在成为世界关注的问题。研究报告了滥用曲马多的个体癫痫发作的潜在风险。在这里,我们提出的情况下,22岁的女性表现为全身性强直阵挛发作发作后口服摄入1900至2100毫克曲马多,并简要的文献回顾。此外,该病例在曲马多剂量逐渐减少、降级和停药期后出现癫痫发作表现。该病例还表明,尽管氟西汀是为了缓解她的压力,但在她渴望的日子里,患者受益于氟西汀。此外,该病例出院后出现曲马多滥用复发和癫痫诱发。我们建议临床医生关注曲马多戒断和中毒期间癫痫发作的潜在发生。需要进行进一步的研究以确定曲马多使用与癫痫发作的机制和关系。复发预防需要一个长期的策略,持续的动机访谈和维持生物治疗。
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Seizure as a rare presentation of tramadol intoxication/withdrawal and fluoxetine as a potential anti-craving agent during tramadol abuse treatment

Tramadol is a centrally acting analgesic with opioid and monoaminergic actions. Tramadol is commonly prescribed for the treatment of moderately severe pain conditions. However, non-medical use of tramadol as well as tramadol poisoning is becoming a world concern. Studies have reported the potential risk of seizures in individuals who abuse tramadol. Here, we present the case of a 22-year-old female presenting with episodes of generalized tonic-clonic seizures after orally ingesting 1900 to 2100 mg tramadol, with a brief literature review. In addition, the case presented with seizure manifestations after tramadol dose tapering, de-escalation, and withdrawal periods. The case also presented that the patient benefited from fluoxetine during her craving days, although fluoxetine was prescribed to relive her stress. In addition, the case presented with tramadol abuse relapse and seizure induction after discharge. We suggest clinicians to focus on the potential occurrence of seizures during tramadol withdrawal and intoxication periods. Further studies need to be performed to identify the mechanisms and relationship of tramadol use with the onset of seizures. Relapse prevention needs to be a long-term strategy with continuous motivational interview and maintenance biological treatment.

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Psychiatry research case reports
Psychiatry research case reports Medicine and Dentistry (General)
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