密度抑制运动模型的稳态和模式形成

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2021-04-01 DOI:10.1093/imamat/hxab006
Zhi-An Wang;Xin Xu
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引用次数: 18

摘要

本文考虑Fu et al.(2012)和Liu et al.(2011)提出的密度抑制运动模型在一维具有Neumman边界条件的平稳性问题。该模型由具有交叉扩散和简并的抛物型方程组成。利用全局分岔理论和Helly紧性定理,探讨了非常平稳(模式)解存在的条件和当某参数值较小时解的渐近轮廓。当不考虑细胞生长时,我们可以将化学扩散速率作为分岔参数来显示解的单调性,从而得到全局分岔图。进一步,我们证明了当化学扩散速率趋于零时,解具有边界尖峰,并确定了非常数解不存在的条件。当转化为具体的运动函数时,我们的结果确实给出了非常平稳解存在的尖锐条件。但随着细胞的增长,全局分岔图的结构变得复杂,特别是解的单调性逐渐丧失。通过将增长率作为分岔参数,我们确定了增长率的最小范围,在此范围内保证了非常平稳解,而在特殊情况下仍然可以得到全局分岔图。我们使用数值模拟来测试我们的分析结果,并说明模式可能非常复杂,当参数值超出我们论文中确定的最小范围时,稳定的固定解可能不存在。
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Steady states and pattern formation of the density-suppressed motility model
This paper considers the stationary problem of density-suppressed motility models proposed in Fu et al. (2012) and Liu et al. (2011) in one dimension with Neumman boundary conditions. The models consist of parabolic equations with cross-diffusion and degeneracy. We employ the global bifurcation theory and Helly compactness theorem to explore the conditions under which non-constant stationary (pattern) solutions exist and asymptotic profiles of solutions as some parameter value is small. When the cell growth is not considered, we are able to show the monotonicity of solutions and hence achieve a global bifurcation diagram by treating the chemical diffusion rate as a bifurcation parameter. Furthermore, we show that the solutions have boundary spikes as the chemical diffusion rate tends to zero and identify the conditions for the non-existence of non-constant solutions. When transformed to specific motility functions, our results indeed give sharp conditions on the existence of non-constant stationary solutions. While with the cell growth, the structure of global bifurcation diagram is much more complicated and in particular the solution loses the monotonicity property. By treating the growth rate as a bifurcation parameter, we identify a minimum range of growth rate in which non-constant stationary solutions are warranted, while a global bifurcation diagram can still be attained in a special situation. We use numerical simulations to test our analytical results and illustrate that patterns can be very intricate and stable stationary solutions may not exist when the parameter value is outside the minimal range identified in our paper.
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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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