孕产妇心血管健康的差异

Janet I Ma, D. Defaria Yeh, Ada C. Stefanescu Schmidt
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Recent studies worldwide have also begun to elucidate the longterm consequences of pregnancyrelated cardiovascular conditions such as gestational hypertension or preeclampsia 6 ; for instance, a largescale population study in the UK found hypertensive disorders of pregnancy increased risk across a multitude of cardiovascular disorders with the impact starting soon after pregnancy. In the USA, preeclampsiarelated deaths have decreased in the last two decades, while deaths associated with or due to chronic hypertension have been increasing. However, one striking difference between the USA and similarly wealthy countries, which may contribute to rising maternal mortality, is its fragmented insurance coverage. Marschner et al give readers a revealing snapshot of the intersection between cardiovascular maternal health and insurance coverage in an important and unique US demographic, pregnant women covered under Medicaid. As the US public insurance programme aimed to improve access to basic healthcare for those otherwise cannot afford it, Medicaid plays a pivotal role in supporting pregnant women living in poverty and currently provides coverage for half of all US births. Marschner et al take a deeper dive into the Medicaid population by exploring pregnancyrelated cardiovascular conditions and early postnatal adverse outcomes among Medicaidinsured pregnant women in three states in the USA between 2015 and 2019. They found that a striking onefourth of these women were diagnosed with a pregnancyrelated cardiometabolic condition, including hypertensive disorders of pregnancy and gestational or preexisting diabetes. Furthermore, between pregnancy and 60 days after delivery, over onetenth of these women were found to have a severe cardiovascular outcome, including heart failure, pulmonary embolism, stroke, cardiac arrest and myocardial infarction. Their study concluded that any type of pregnancyrelated cardiometabolic condition is associated with a threefold higher risk of a severe cardiovascular outcome. Marschner et al point out that current literature suggests the Medicaid population is at much higher risk of pregnancyrelated cardiometabolic conditions compared with those who have private insurance. Their analysis is based on claims data submitted to one Medicaid management company (the major company in Ohio, and a minority of Medicaid patients in Georgia and Indiana). As such, there may be a tendency for overcoding, and there are no clinical data to confirm the accuracy of the billed diagnoses—to differentiate between preeclampsia and heart failure, for instance. While Marschner et al add compelling data that further elucidate the rise in adverse US maternal health outcomes, it is important to note that it only provides a small glimpse into the stark disparities that underlie its findings. First, over onefourth of Medicaidinsured pregnant women were uninsured before their pregnancy, making the distinction between preexisting cardiometabolic conditions and pregnancyrelated cardiometabolic conditions more difficult. This then leads to difficulty in distinguishing cardiovascular complications arising specifically from pregnancy, such as preeclampsia, with cardiovascular disease noted during pregnancy such as hypertension or heart failure. Furthermore, the study only examined adverse cardiovascular outcomes up to 60 days post partum, whereas most maternal deaths have been found to occur in the 42–365 days after birth, suggesting the already high cardiovascular burden risk in the postpartum period for Medicaidinsured pregnant women with cardiometabolic conditions may even be an underestimate. This limitation in data likely comes from a federal mandate only requiring health insurance coverage for pregnant women through 60 days post partum; while the majority of states have expanded this coverage up to a year, a number of states still have yet to do so, and over onefifth of Medicaidinsured pregnant women lose insurance 2–6 months after giving birth. Perhaps one of the most understated aspects in this study is its allusion to the striking racial disparities underpinning adverse cardiovascular maternal health outcomes. Black maternal mortality accounts for a skewed proportion of total US maternal deaths, with Black women up to three times more likely to die compared with their White counterparts. 2 The reasons for this are likely multifactorial, including unconscious provider bias, and the study acknowledged limitations in ethnicity data collection and therefore direct examination of racial disparities within the Medicaid population. However, a disproportionate lack of access to care as a driving factor may be extrapolated when taking the study’s mention that the Medicaid population ‘skews nonWhite, with 65% of Black women being covered by Medicaid.’ The issues Marschner et al highlight by focusing on a Medicaidinsured population demonstrate policy solutions will be a key aspect of providing equitable care and reducing disparities in cardiovascular maternal health. Indeed, extending Medicaid coverage for postpartum women past 60 days for up to 6–12 months has been shown to reduce cardiovascular maternal mortality through improved access to care for women who would otherwise lose insurance. In March 2021, the American Rescue Plan Act of 2021 was passed by Congress which included a provision allowing states the option to extend Medicaid for up to 1 year post partum; states that opt in could receive their regular federal matching rate for the additional 10 months of coverage they provided. Additionally, the Black Maternal Health Momnibus Act of 2021 has been introduced in the US Congress as a package of 12 comprehensive evidencebased bills to improve Black maternal health, including improvement in data collection and quality measures as well as ensuring Heart Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA","PeriodicalId":9311,"journal":{"name":"British Heart Journal","volume":"108 1","pages":"1504 - 1505"},"PeriodicalIF":0.0000,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Disparities in cardiovascular maternal health\",\"authors\":\"Janet I Ma, D. Defaria Yeh, Ada C. 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Recent studies worldwide have also begun to elucidate the longterm consequences of pregnancyrelated cardiovascular conditions such as gestational hypertension or preeclampsia 6 ; for instance, a largescale population study in the UK found hypertensive disorders of pregnancy increased risk across a multitude of cardiovascular disorders with the impact starting soon after pregnancy. In the USA, preeclampsiarelated deaths have decreased in the last two decades, while deaths associated with or due to chronic hypertension have been increasing. However, one striking difference between the USA and similarly wealthy countries, which may contribute to rising maternal mortality, is its fragmented insurance coverage. Marschner et al give readers a revealing snapshot of the intersection between cardiovascular maternal health and insurance coverage in an important and unique US demographic, pregnant women covered under Medicaid. As the US public insurance programme aimed to improve access to basic healthcare for those otherwise cannot afford it, Medicaid plays a pivotal role in supporting pregnant women living in poverty and currently provides coverage for half of all US births. Marschner et al take a deeper dive into the Medicaid population by exploring pregnancyrelated cardiovascular conditions and early postnatal adverse outcomes among Medicaidinsured pregnant women in three states in the USA between 2015 and 2019. They found that a striking onefourth of these women were diagnosed with a pregnancyrelated cardiometabolic condition, including hypertensive disorders of pregnancy and gestational or preexisting diabetes. Furthermore, between pregnancy and 60 days after delivery, over onetenth of these women were found to have a severe cardiovascular outcome, including heart failure, pulmonary embolism, stroke, cardiac arrest and myocardial infarction. Their study concluded that any type of pregnancyrelated cardiometabolic condition is associated with a threefold higher risk of a severe cardiovascular outcome. Marschner et al point out that current literature suggests the Medicaid population is at much higher risk of pregnancyrelated cardiometabolic conditions compared with those who have private insurance. Their analysis is based on claims data submitted to one Medicaid management company (the major company in Ohio, and a minority of Medicaid patients in Georgia and Indiana). As such, there may be a tendency for overcoding, and there are no clinical data to confirm the accuracy of the billed diagnoses—to differentiate between preeclampsia and heart failure, for instance. While Marschner et al add compelling data that further elucidate the rise in adverse US maternal health outcomes, it is important to note that it only provides a small glimpse into the stark disparities that underlie its findings. First, over onefourth of Medicaidinsured pregnant women were uninsured before their pregnancy, making the distinction between preexisting cardiometabolic conditions and pregnancyrelated cardiometabolic conditions more difficult. This then leads to difficulty in distinguishing cardiovascular complications arising specifically from pregnancy, such as preeclampsia, with cardiovascular disease noted during pregnancy such as hypertension or heart failure. Furthermore, the study only examined adverse cardiovascular outcomes up to 60 days post partum, whereas most maternal deaths have been found to occur in the 42–365 days after birth, suggesting the already high cardiovascular burden risk in the postpartum period for Medicaidinsured pregnant women with cardiometabolic conditions may even be an underestimate. This limitation in data likely comes from a federal mandate only requiring health insurance coverage for pregnant women through 60 days post partum; while the majority of states have expanded this coverage up to a year, a number of states still have yet to do so, and over onefifth of Medicaidinsured pregnant women lose insurance 2–6 months after giving birth. Perhaps one of the most understated aspects in this study is its allusion to the striking racial disparities underpinning adverse cardiovascular maternal health outcomes. Black maternal mortality accounts for a skewed proportion of total US maternal deaths, with Black women up to three times more likely to die compared with their White counterparts. 2 The reasons for this are likely multifactorial, including unconscious provider bias, and the study acknowledged limitations in ethnicity data collection and therefore direct examination of racial disparities within the Medicaid population. However, a disproportionate lack of access to care as a driving factor may be extrapolated when taking the study’s mention that the Medicaid population ‘skews nonWhite, with 65% of Black women being covered by Medicaid.’ The issues Marschner et al highlight by focusing on a Medicaidinsured population demonstrate policy solutions will be a key aspect of providing equitable care and reducing disparities in cardiovascular maternal health. Indeed, extending Medicaid coverage for postpartum women past 60 days for up to 6–12 months has been shown to reduce cardiovascular maternal mortality through improved access to care for women who would otherwise lose insurance. In March 2021, the American Rescue Plan Act of 2021 was passed by Congress which included a provision allowing states the option to extend Medicaid for up to 1 year post partum; states that opt in could receive their regular federal matching rate for the additional 10 months of coverage they provided. 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引用次数: 1

摘要

尽管全球孕产妇死亡率在过去三十年中有所下降,但与妊娠相关的死亡在美国仍然普遍存在,即使考虑到根据死亡证明的变化可能出现的过度报告。2017年,每10万活产中约有17名美国母亲死于妊娠或分娩并发症;相比之下,当年每10万名活产婴儿中只有7名英国母亲死亡。美国多达三分之二的孕产妇死亡可能是可以预防的。心血管疾病已成为当前孕产妇死亡率的驱动因素,导致或与超过三分之一的美国孕产妇死亡有关,大多数死亡发生在分娩期间或分娩后。世界各地最近的研究也开始阐明妊娠相关心血管疾病的长期后果,如妊娠期高血压或先兆子痫6;例如,英国的一项大规模人群研究发现,妊娠期高血压疾病会增加多种心血管疾病的风险,其影响从妊娠后不久开始。在美国,先兆子痫相关的死亡人数在过去二十年中有所下降,而与慢性高血压相关或由慢性高血压引起的死亡人数一直在增加。然而,美国与同样富裕的国家之间的一个显著区别是其分散的保险覆盖范围,这可能会导致孕产妇死亡率上升。Marschner等人为读者提供了心血管孕产妇健康和保险覆盖之间的交叉点,这是美国一个重要而独特的人口群体,即医疗补助覆盖的孕妇。由于美国公共保险计划旨在改善那些负担不起的人获得基本医疗保健的机会,医疗补助在支持贫困孕妇方面发挥着关键作用,目前为美国一半的新生儿提供了保险。Marschner等人通过探索2015年至2019年间美国三个州接受医疗补助的孕妇的妊娠相关心血管疾病和产后早期不良后果,对医疗补助人群进行了更深入的研究。他们发现,这些女性中惊人的四分之一被诊断出患有与妊娠相关的心脏代谢疾病,包括妊娠期高血压疾病和妊娠期或先前存在的糖尿病。此外,在怀孕至产后60天期间,这些女性中有超过一分之一的人出现了严重的心血管后果,包括心力衰竭、肺栓塞、中风、心脏骤停和心肌梗死。他们的研究得出结论,任何类型的妊娠相关心脏代谢状况都与严重心血管后果的风险高出三倍有关。Marschner等人指出,目前的文献表明,与拥有私人保险的人群相比,医疗补助人群患妊娠相关心脏代谢疾病的风险要高得多。他们的分析基于提交给一家医疗补助管理公司(俄亥俄州的主要公司,以及佐治亚州和印第安纳州的少数医疗补助患者)的索赔数据。因此,可能存在过度编码的趋势,而且没有临床数据来证实账单诊断的准确性——例如,区分先兆子痫和心力衰竭。虽然Marschner等人补充了令人信服的数据,进一步阐明了美国不良孕产妇健康结果的增加,但值得注意的是,这只是对其研究结果背后的明显差异的一小部分了解。首先,超过四分之一的有医疗保险的孕妇在怀孕前没有保险,这使得区分先前存在的心脏代谢状况和与怀孕相关的心脏代谢状态变得更加困难。这就导致很难区分妊娠期特有的心血管并发症,如先兆子痫,以及妊娠期常见的心血管疾病,如高血压或心力衰竭。此外,该研究只检查了产后60天内的不良心血管后果,而大多数产妇的死亡发生在产后42-365天,这表明患有心脏代谢疾病的孕妇在产后已经很高的心血管负担风险可能被低估了。数据的这种限制可能来自于一项联邦命令,该命令只要求孕妇在产后60天内享有医疗保险;虽然大多数州已经将这一覆盖范围扩大到一年,但一些州仍然没有这样做,超过五分之一的有医疗保险的孕妇在分娩后2-6个月就失去了保险。也许这项研究中最低调的一个方面是它暗示了严重的种族差异,而种族差异正是不利的心血管孕产妇健康结果的基础。
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Disparities in cardiovascular maternal health
While global maternal mortality has decreased in the last three decades, pregnancyrelated deaths remain prevalent in the USA, even after accounting for possible overreporting based on changes in death certificates. In 2017, approximately 17 US mothers per 100 000 live births died due to complications related to pregnancy or childbirth; in contrast, only 7 UK mothers per 100 000 live births died that year. Up to twothirds of US maternal deaths may have been preventable. Cardiovascular disease has emerged as the driving cause of current maternal mortality rates, causing or related to over onethird of US maternal deaths, with most deaths occurring during or after delivery. Recent studies worldwide have also begun to elucidate the longterm consequences of pregnancyrelated cardiovascular conditions such as gestational hypertension or preeclampsia 6 ; for instance, a largescale population study in the UK found hypertensive disorders of pregnancy increased risk across a multitude of cardiovascular disorders with the impact starting soon after pregnancy. In the USA, preeclampsiarelated deaths have decreased in the last two decades, while deaths associated with or due to chronic hypertension have been increasing. However, one striking difference between the USA and similarly wealthy countries, which may contribute to rising maternal mortality, is its fragmented insurance coverage. Marschner et al give readers a revealing snapshot of the intersection between cardiovascular maternal health and insurance coverage in an important and unique US demographic, pregnant women covered under Medicaid. As the US public insurance programme aimed to improve access to basic healthcare for those otherwise cannot afford it, Medicaid plays a pivotal role in supporting pregnant women living in poverty and currently provides coverage for half of all US births. Marschner et al take a deeper dive into the Medicaid population by exploring pregnancyrelated cardiovascular conditions and early postnatal adverse outcomes among Medicaidinsured pregnant women in three states in the USA between 2015 and 2019. They found that a striking onefourth of these women were diagnosed with a pregnancyrelated cardiometabolic condition, including hypertensive disorders of pregnancy and gestational or preexisting diabetes. Furthermore, between pregnancy and 60 days after delivery, over onetenth of these women were found to have a severe cardiovascular outcome, including heart failure, pulmonary embolism, stroke, cardiac arrest and myocardial infarction. Their study concluded that any type of pregnancyrelated cardiometabolic condition is associated with a threefold higher risk of a severe cardiovascular outcome. Marschner et al point out that current literature suggests the Medicaid population is at much higher risk of pregnancyrelated cardiometabolic conditions compared with those who have private insurance. Their analysis is based on claims data submitted to one Medicaid management company (the major company in Ohio, and a minority of Medicaid patients in Georgia and Indiana). As such, there may be a tendency for overcoding, and there are no clinical data to confirm the accuracy of the billed diagnoses—to differentiate between preeclampsia and heart failure, for instance. While Marschner et al add compelling data that further elucidate the rise in adverse US maternal health outcomes, it is important to note that it only provides a small glimpse into the stark disparities that underlie its findings. First, over onefourth of Medicaidinsured pregnant women were uninsured before their pregnancy, making the distinction between preexisting cardiometabolic conditions and pregnancyrelated cardiometabolic conditions more difficult. This then leads to difficulty in distinguishing cardiovascular complications arising specifically from pregnancy, such as preeclampsia, with cardiovascular disease noted during pregnancy such as hypertension or heart failure. Furthermore, the study only examined adverse cardiovascular outcomes up to 60 days post partum, whereas most maternal deaths have been found to occur in the 42–365 days after birth, suggesting the already high cardiovascular burden risk in the postpartum period for Medicaidinsured pregnant women with cardiometabolic conditions may even be an underestimate. This limitation in data likely comes from a federal mandate only requiring health insurance coverage for pregnant women through 60 days post partum; while the majority of states have expanded this coverage up to a year, a number of states still have yet to do so, and over onefifth of Medicaidinsured pregnant women lose insurance 2–6 months after giving birth. Perhaps one of the most understated aspects in this study is its allusion to the striking racial disparities underpinning adverse cardiovascular maternal health outcomes. Black maternal mortality accounts for a skewed proportion of total US maternal deaths, with Black women up to three times more likely to die compared with their White counterparts. 2 The reasons for this are likely multifactorial, including unconscious provider bias, and the study acknowledged limitations in ethnicity data collection and therefore direct examination of racial disparities within the Medicaid population. However, a disproportionate lack of access to care as a driving factor may be extrapolated when taking the study’s mention that the Medicaid population ‘skews nonWhite, with 65% of Black women being covered by Medicaid.’ The issues Marschner et al highlight by focusing on a Medicaidinsured population demonstrate policy solutions will be a key aspect of providing equitable care and reducing disparities in cardiovascular maternal health. Indeed, extending Medicaid coverage for postpartum women past 60 days for up to 6–12 months has been shown to reduce cardiovascular maternal mortality through improved access to care for women who would otherwise lose insurance. In March 2021, the American Rescue Plan Act of 2021 was passed by Congress which included a provision allowing states the option to extend Medicaid for up to 1 year post partum; states that opt in could receive their regular federal matching rate for the additional 10 months of coverage they provided. Additionally, the Black Maternal Health Momnibus Act of 2021 has been introduced in the US Congress as a package of 12 comprehensive evidencebased bills to improve Black maternal health, including improvement in data collection and quality measures as well as ensuring Heart Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
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