短链脂肪酸和胃肠道激素减轻高脂饲料喂养的大鼠肠道屏障破坏补充合成

IF 0.7 Q4 NUTRITION & DIETETICS Mediterranean Journal of Nutrition and Metabolism Pub Date : 2023-06-10 DOI:10.3233/mnm-230026
Bataa Mohamed EL Kafoury, Asmaa Tarek Ebrahim, Manal Said Abd-El Hamid Ali, Nayra Shaker Mehanna, Gamil El-Sayed Ibrahim Ramadan, Wessam Ezzat Morsy
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引用次数: 0

摘要

高脂肪饮食(HFD)易引起许多代谢变化;它可能破坏肠道屏障的完整性和肠道微生物群的组成。合生素补充可以通过选择性激活健康微生物来促进宿主的代谢健康。本研究旨在探讨HFD状态下合生元补充剂、肠道微生物群和肠道激素之间的相互作用。27只成年雄性白化大鼠,3组,第一组:对照组,第二组:HFD接受HFD治疗12周,第三组:补充合生元的HFD在最后6周接受合生元治疗。测量了人体测量。评估肝脏转氨酶、脂质状况、胰岛素抵抗参数、血清5-羟色胺、胰高血糖素样多肽-1(GLP-1)、氧化剂/抗氧化标志物(MDA/GPx)、zonulin水平和定量盲肠短链脂肪酸(SCFA)。肝脏和结肠样本用于组织病理学研究。与HFD组相比,合生元导致人体测量、肝酶、动脉粥样硬化指数、HOMA-IR和MDA显著降低,表明血脂异常、胰岛素抵抗和氧化状态得到改善。此外,补充合生元降低了血清zonulin,并增加了血清血清素、GLP-1和盲肠SCFAs。合生素补充改善了HFD引起的代谢紊乱和肠道屏障完整性紊乱。合生元可以增加肠道激素(血清GLP-1和血清素)和短链脂肪酸。
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Short chain fatty acids and GIT hormones mitigate gut barrier disruption in high fat diet fed rats supplemented by synbiotics
High fat diet (HFD) predisposes to many metabolic changes; it may disrupt gut barrier integrity and gut microbiota composition. Synbiotic supplementation may promote host’s metabolic health by selective activation of the healthy microorganisms. This study aimed to probe the interaction between synbiotic supplementation, gut microbiota and gut hormones in HFD states. Twenty-seven adult male albino rats, 3 groups, group I: control, group II: HFD received HFD for 12 weeks and group III: synbiotic-supplemented HFD received synbiotic in the last 6 weeks. The anthropometric measurments were measured. Liver transaminases, lipid profile, parameters of insulin resistance, serum serotonin, glucagon like polypeptide-1 (GLP-1), oxidant/antioxidant markers (MDA/GPx), zonulin levels and quantitative cecal short chain fatty acids (SCFA) were assessed. Samples of liver and colon were employed for histopathological studies. Compared to HFD group, synbiotic led to a significant reduction in anthropometric measurements, liver enzymes, atherogenic index, HOMA-IR and MDA denoting improved dyslipidemia, insulin resistance and oxidative state. Moreover, synbiotic supplementation decreased serum zonulin and increased both serum serotonin, GLP-1 and cecal SCFAs. Synbiotic supplementation ameliorated the metabolic derangements and the disturbed integrity of the intestinal barrier induced by HFD. As synbiotics can increase gut hormones (serum GLP-1&serotonin) and SCFAs.
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来源期刊
CiteScore
1.70
自引率
9.10%
发文量
35
期刊介绍: The Mediterranean Journal of Nutrition and Metabolism publishes original scientific papers on metabolism, including diabesity and eating disorders; nutrition (epidemiological, basic, clinical and artificial); dietary and nutritional practices and management and their impact on health from prevention to treatment. The journal hosts the proceedings of relevant congresses and presents shorter notices focused on the original character of the Mediterranean nutritional civilisation. In addition, this journal is intended as a platform for scientific debate and knowledge-sharing among students and clinical practitioners, and between them and the broader scientific community, and finally as a tool for promoting and enhancing scientific cooperation.
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