靶向垂体腺瘤的叶酸缀合多种药物修饰脂质体制剂,以提高抗增殖抗癌功效

IF 2.6 4区 材料科学 Q2 CHEMISTRY, MULTIDISCIPLINARY Journal of Experimental Nanoscience Pub Date : 2021-12-20 DOI:10.1080/17458080.2021.2016711
Changwei Hu, Xirui Wang, Yabin Li, Xiao Han, Baowen Ren, Gangfeng Yin
{"title":"靶向垂体腺瘤的叶酸缀合多种药物修饰脂质体制剂,以提高抗增殖抗癌功效","authors":"Changwei Hu, Xirui Wang, Yabin Li, Xiao Han, Baowen Ren, Gangfeng Yin","doi":"10.1080/17458080.2021.2016711","DOIUrl":null,"url":null,"abstract":"Abstract In this work, we synthesized folate-conjugated dual-drug loaded double liposomes which are noted for their extremely high target specificity towards pituitary adenomas. It is known that while folate receptors are almost non-existent in normal tissues, they are overexpressed in non-functional pituitary adenomas. Synthesis, characterization and in vitro studies of folate-conjugated dual-drug loaded double liposomes for targeting non-functional pituitary adenomas is the highlight of this study. The size, zeta-potential, polydispersity index, in vitro release studies, stability of the nanoformulation, cytotoxicity and cellular uptake studies have been carried out. It was noted from the results that these are highly targeted liposomal formulation as expressed by the cellular uptake studies and are just sufficiently sized to escape the clearance mechanisms of body. They were also cytocompatible and were stable even after 60 days of shelf life with negligible changes in sizes, zeta potential as well as polydispersity index. The conjugation with folate particles resulted in the high specificity of the formulation to the specific targeted tissue as seen in cellular uptake by primary cell culture of non-functional pituitary adenomas. It may safely be concluded from the results that this approach may be a promising therapy for the future which has low cytotoxicity and high-specificity.","PeriodicalId":15673,"journal":{"name":"Journal of Experimental Nanoscience","volume":"17 1","pages":"14 - 33"},"PeriodicalIF":2.6000,"publicationDate":"2021-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Targeting pituitary adenomas with folate-conjugated multiple drug decorated liposomal formulations for improved antiproliferative anticancer efficacy\",\"authors\":\"Changwei Hu, Xirui Wang, Yabin Li, Xiao Han, Baowen Ren, Gangfeng Yin\",\"doi\":\"10.1080/17458080.2021.2016711\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Abstract In this work, we synthesized folate-conjugated dual-drug loaded double liposomes which are noted for their extremely high target specificity towards pituitary adenomas. It is known that while folate receptors are almost non-existent in normal tissues, they are overexpressed in non-functional pituitary adenomas. Synthesis, characterization and in vitro studies of folate-conjugated dual-drug loaded double liposomes for targeting non-functional pituitary adenomas is the highlight of this study. The size, zeta-potential, polydispersity index, in vitro release studies, stability of the nanoformulation, cytotoxicity and cellular uptake studies have been carried out. It was noted from the results that these are highly targeted liposomal formulation as expressed by the cellular uptake studies and are just sufficiently sized to escape the clearance mechanisms of body. They were also cytocompatible and were stable even after 60 days of shelf life with negligible changes in sizes, zeta potential as well as polydispersity index. The conjugation with folate particles resulted in the high specificity of the formulation to the specific targeted tissue as seen in cellular uptake by primary cell culture of non-functional pituitary adenomas. It may safely be concluded from the results that this approach may be a promising therapy for the future which has low cytotoxicity and high-specificity.\",\"PeriodicalId\":15673,\"journal\":{\"name\":\"Journal of Experimental Nanoscience\",\"volume\":\"17 1\",\"pages\":\"14 - 33\"},\"PeriodicalIF\":2.6000,\"publicationDate\":\"2021-12-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Experimental Nanoscience\",\"FirstCategoryId\":\"88\",\"ListUrlMain\":\"https://doi.org/10.1080/17458080.2021.2016711\",\"RegionNum\":4,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Experimental Nanoscience","FirstCategoryId":"88","ListUrlMain":"https://doi.org/10.1080/17458080.2021.2016711","RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0

摘要

在这项工作中,我们合成了叶酸偶联的双药负载双脂质体,该脂质体对垂体腺瘤具有极高的靶向特异性。众所周知,虽然叶酸受体在正常组织中几乎不存在,但它们在无功能垂体腺瘤中过度表达。针对无功能垂体腺瘤的叶酸偶联双药双脂质体的合成、表征和体外研究是本研究的重点。进行了大小、ζ电位、多分散指数、体外释放研究、纳米制剂稳定性、细胞毒性和细胞摄取研究。结果表明,细胞摄取研究表明,这些是高度靶向的脂质体制剂,其大小正好可以逃脱身体的清除机制。它们还具有细胞相容性,即使在60天的保质期后也很稳定,大小、zeta电位和多分散性指数的变化可以忽略不计。与叶酸颗粒的结合导致该制剂对特定目标组织的高特异性,这在无功能垂体腺瘤的原代细胞培养的细胞摄取中可见。结果表明,该方法具有低细胞毒性和高特异性,是一种很有前途的治疗方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
Targeting pituitary adenomas with folate-conjugated multiple drug decorated liposomal formulations for improved antiproliferative anticancer efficacy
Abstract In this work, we synthesized folate-conjugated dual-drug loaded double liposomes which are noted for their extremely high target specificity towards pituitary adenomas. It is known that while folate receptors are almost non-existent in normal tissues, they are overexpressed in non-functional pituitary adenomas. Synthesis, characterization and in vitro studies of folate-conjugated dual-drug loaded double liposomes for targeting non-functional pituitary adenomas is the highlight of this study. The size, zeta-potential, polydispersity index, in vitro release studies, stability of the nanoformulation, cytotoxicity and cellular uptake studies have been carried out. It was noted from the results that these are highly targeted liposomal formulation as expressed by the cellular uptake studies and are just sufficiently sized to escape the clearance mechanisms of body. They were also cytocompatible and were stable even after 60 days of shelf life with negligible changes in sizes, zeta potential as well as polydispersity index. The conjugation with folate particles resulted in the high specificity of the formulation to the specific targeted tissue as seen in cellular uptake by primary cell culture of non-functional pituitary adenomas. It may safely be concluded from the results that this approach may be a promising therapy for the future which has low cytotoxicity and high-specificity.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Journal of Experimental Nanoscience
Journal of Experimental Nanoscience 工程技术-材料科学:综合
CiteScore
4.10
自引率
25.00%
发文量
39
审稿时长
6.5 months
期刊介绍: Journal of Experimental Nanoscience, an international and multidisciplinary journal, provides a showcase for advances in the experimental sciences underlying nanotechnology and nanomaterials. The journal exists to bring together the most significant papers making original contributions to nanoscience in a range of fields including biology and biochemistry, physics, chemistry, chemical, electrical and mechanical engineering, materials, pharmaceuticals and medicine. The aim is to provide a forum in which cross fertilization between application areas, methodologies, disciplines, as well as academic and industrial researchers can take place and new developments can be encouraged.
期刊最新文献
Inhibition of restenosis after balloon injury in rabbit vessels by integrin αvβ3-targeted 10058-F4 nanoparticles Enhancing structural and optical properties of titanium dioxide nanoparticles (TiO2 NPs) incorporating with indium tin oxide nanoparticles (ITO NPs): effects of annealing temperature Alginate-wrapped NiO-ZnO nanocomposites-based catalysts for water treatment Evolution of the precursor structure during the preparation of the nanopowders with perovskite-type LnLn’O3 (Ln, Ln’ = REE) complex oxide phase in the La2O3-Lu2O3-Yb2O3 system Statement of Retraction: Image processing algorithm for mechanical properties testing of high temperature materials based on time‐frequency analysis
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1