Implementation and effect estimation by Taguchi orthogonal array design for Metoprolol Sustained Release Tablets

ABSTRACT The purpose of this study was to evaluate the influence of variables on dosage form development using a Taguchi orthogonal array design. By implementing the design, a total of nine sustained-release Metoprolol tartrate tablet formulations were created. In addition to four responses, four independent variables, including METHOCEL K15M, HPMC K100, Guar gum, and Pectic polysaccharide, were analyzed. In addition to evaluating formulations for hardness, swelling index, drug release percentage, and friability, a release kinetics study is conducted. Half normal plots and interaction plots were drawn to identify significant factors and study their interactions. The data were analyzed using statistical modeling, with the process order being design model and the model type being factorial with main effect determination. Formulation ‘F1’ was determined to be the best and most optimized formulation, and it was further characterized by attenuated total reflectance, differential scanning calorimetry, and X-ray diffraction studies. Additionally, the formulation was evaluated for stability in accordance with ICH guidelines, which revealed that it was sufficiently stable. GRAPHICAL ABSTRACT