临时膜覆盖自扩张金属支架UVENTATM治疗复发性球尿道狭窄

IF 2 Q2 UROLOGY & NEPHROLOGY Research and Reports in Urology Pub Date : 2022-05-01 DOI:10.2147/RRU.S363557
Ibrahim Alnadhari, Nabil N. Moohialdin, V. Sampige, O. Ali, Osama Abdeljaleel, M. Salah, O. Sedigh, A. Shamsodini, A. Al-Ansari
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引用次数: 1

摘要

引言复发性尿道狭窄是一个真正的挑战。有趣的是,最近有报道称,使用具有聚四氟乙烯(PTFE)膜涂层的临时双层自膨胀镍钛诺尿道支架(UventaTM,Taewoong Medical,South Korea)治疗复发性尿道狭窄具有良好的短期效果。然而,大多数报道的研究都是以病例报告或微小数字病例系列的摘要形式发表的。我们研究的目的是评估这种临时尿道支架在尿道成形术后和多次尿道内切开术后复发性尿道狭窄患者中的效果。材料和方法在这项回顾性研究中,22名患者因复发性延髓狭窄而放置了双层PTFE膜自膨胀支架(Uventa,Taewoong Medical)。本研究包括2017年至2020年间的病例。每例患者的狭窄情况均采用尿流量测定法和上行尿道造影术进行评估。人口统计学和临床特征的数据包括年龄、病因、狭窄的位置和长度,以及最大尿流量(Qmax)、既往干预次数和支架相关并发症。结果在中位随访17个月(2-4 4个月)时,13/22(59.1%)的患者获得了总体临床成功。支架置入前、术后3个月、6个月和12个月的平均最大尿流量分别为7.07±3.55mL/s、23.50±10.41mL/s、21.41±15.55mL/s、14.88±9.77和17.63±12.28mL/s。结论在我们的研究中,在中位随访17个月时,临时尿道支架置入的成功率保持在59.1%。我们的结论是,需要进一步的随机对照研究和长期随访来全面评估结果。
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Use of Temporary Membrane-Covered Self-Expandable Metallic Stent – UVENTATM for Treatment of Recurrent Bulbar Urethral Stricture
Introduction Recurrent urethral stricture is a real challenge. Interestingly use of temporary double layered self-expanding nitinol urethral stent with polytetrafluoroethylene (PTFE) membrane coating (UventaTM, Taewoong Medical, South Korea) has been recently reported with promising short-term results in recurrent urethral stricture. However most of the reported studies are published as abstracts of either case reports or case series of miniscule numbers. The aim of our study is to evaluate the outcome of this temporary urethral stent in patients with recurrent urethral stricture after urethroplasty as well as after multiple visual internal urethrotomy. Materials and Methods In this retrospective study, 22 patients had placement of double-layered self-expanding stent with PTFE membrane coating (Uventa, Taewoong Medical) for recurrent bulbar strictures. The present study included cases between 2017 and 2020. The stricture in each patient were evaluated with Uroflowmetry and ascending urethrography. The data of demographic and clinical characteristics included age, aetiology, location and length of stricture, along with maximum urinary flow rate (Qmax), number of previous interventions, and stent-related complications. Results The overall clinical success was achieved in 13/22 (59.1%) of patients at a median follow-up of 17 months (range 2–44). The mean maximum urine flow rates were 7.07 ± 3.55mL/sec, 23.50 ± 10.41mL/sec, 21.41± 15.55 mL/sec, 14.88 ± 9.77 and 17.63 ± 12.28 mL/sec before, while stent in place, at 3 months, 6 months and 12 months after the procedure, respectively. Conclusion In our study, the success rate of temporary urethral stent placement has remained at 59.1% at a median follow-up of 17 months. We conclude that further randomized controlled studies with long-term follow up are required to fully evaluate the outcome.
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来源期刊
Research and Reports in Urology
Research and Reports in Urology UROLOGY & NEPHROLOGY-
CiteScore
3.40
自引率
0.00%
发文量
60
审稿时长
16 weeks
期刊介绍: Research and Reports in Urology is an international, peer-reviewed, open access, online journal. Publishing original research, reports, editorials, reviews and commentaries on all aspects of adult and pediatric urology in the clinic and laboratory including the following topics: Pathology, pathophysiology of urological disease Investigation and treatment of urological disease Pharmacology of drugs used for the treatment of urological disease Although the main focus of the journal is to publish research and clinical results in humans; preclinical, animal and in vitro studies will be published where they will shed light on disease processes and potential new therapies. Issues of patient safety and quality of care will also be considered.
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