{"title":"后基因组时代的同性恋基因","authors":"S. Clare, P. Grzanka, Joanna Wuest","doi":"10.1215/10642684-10144449","DOIUrl":null,"url":null,"abstract":"This roundtable analyzes the first genome-wide association study (GWAS) that sought to identify the genetic variations that correlate with same-sex sexual behavior. Drawing on over 450,000 individuals’ genetic material from the UK Biobank and 23andMe, the 2019 study concluded that “many loci with individually small effects,” which are spread across the entire genome, contribute in statistically significant but highly unreliable ways to an individual's sexual behavior. The study was thus greeted by geneticists, science journalists, and even some LGBTQ+ advocates as heralding the demise of the mythical “gay gene.” However, the study itself did not drive a stake through the heart of the “born this way” idea. In fact, the researchers framed their efforts as having revealed the “genetic architecture”—which is to say the blueprint or design—of same-sex sexual behavior. Stephanie Clare, Patrick R. Grzanka, and Joanna Wuest argue that the 2019 GWAS marks a moment of both flux and continuity: a recognition of sexuality's complexity and contingency alongside a continued affective, ideological, and economic investment in biology's role in telling fundamental truths about behavior and identity. The study's recognition of the complexity of sexuality should not be mistaken as some wish fulfillment of queer theory; rather, the dream of bioessentialism, entangled with its continued production of inequality, is still alive in the postgenomic era.","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":null,"pages":null},"PeriodicalIF":16.4000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Gay Genes in the Postgenomic Era\",\"authors\":\"S. Clare, P. Grzanka, Joanna Wuest\",\"doi\":\"10.1215/10642684-10144449\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"This roundtable analyzes the first genome-wide association study (GWAS) that sought to identify the genetic variations that correlate with same-sex sexual behavior. Drawing on over 450,000 individuals’ genetic material from the UK Biobank and 23andMe, the 2019 study concluded that “many loci with individually small effects,” which are spread across the entire genome, contribute in statistically significant but highly unreliable ways to an individual's sexual behavior. The study was thus greeted by geneticists, science journalists, and even some LGBTQ+ advocates as heralding the demise of the mythical “gay gene.” However, the study itself did not drive a stake through the heart of the “born this way” idea. In fact, the researchers framed their efforts as having revealed the “genetic architecture”—which is to say the blueprint or design—of same-sex sexual behavior. Stephanie Clare, Patrick R. Grzanka, and Joanna Wuest argue that the 2019 GWAS marks a moment of both flux and continuity: a recognition of sexuality's complexity and contingency alongside a continued affective, ideological, and economic investment in biology's role in telling fundamental truths about behavior and identity. The study's recognition of the complexity of sexuality should not be mistaken as some wish fulfillment of queer theory; rather, the dream of bioessentialism, entangled with its continued production of inequality, is still alive in the postgenomic era.\",\"PeriodicalId\":1,\"journal\":{\"name\":\"Accounts of Chemical Research\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":16.4000,\"publicationDate\":\"2023-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Accounts of Chemical Research\",\"FirstCategoryId\":\"90\",\"ListUrlMain\":\"https://doi.org/10.1215/10642684-10144449\",\"RegionNum\":1,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Accounts of Chemical Research","FirstCategoryId":"90","ListUrlMain":"https://doi.org/10.1215/10642684-10144449","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 1
摘要
本次圆桌会议分析了第一个全基因组关联研究(GWAS),该研究旨在确定与同性性行为相关的遗传变异。这项2019年的研究利用了来自英国生物银行和23andMe的45万多人的遗传物质,得出的结论是,“许多个体影响很小的位点”分布在整个基因组中,以统计上显着但极不可靠的方式对个体的性行为做出了贡献。因此,这项研究受到了遗传学家、科学记者,甚至一些LGBTQ+倡导者的欢迎,他们认为这预示着神话般的“同性恋基因”的消亡。然而,这项研究本身并没有刺穿“天生如此”思想的核心。事实上,研究人员将他们的努力描述为揭示了同性性行为的“基因结构”——也就是蓝图或设计。斯蒂芬妮·克莱尔(Stephanie Clare)、帕特里克·r·格赞卡(Patrick R. Grzanka)和乔安娜·韦斯特(Joanna Wuest)认为,2019年的GWAS标志着一个既具有流动性又具有连续性的时刻:人们认识到性的复杂性和偶发性,同时继续在情感、意识形态和经济上投资于生物学在讲述行为和身份的基本真相方面的作用。这项研究对性的复杂性的认识不应被误认为是酷儿理论的某种愿望的实现;相反,生物本质主义的梦想,与其不断产生的不平等纠缠在一起,在后基因组时代仍然存在。
This roundtable analyzes the first genome-wide association study (GWAS) that sought to identify the genetic variations that correlate with same-sex sexual behavior. Drawing on over 450,000 individuals’ genetic material from the UK Biobank and 23andMe, the 2019 study concluded that “many loci with individually small effects,” which are spread across the entire genome, contribute in statistically significant but highly unreliable ways to an individual's sexual behavior. The study was thus greeted by geneticists, science journalists, and even some LGBTQ+ advocates as heralding the demise of the mythical “gay gene.” However, the study itself did not drive a stake through the heart of the “born this way” idea. In fact, the researchers framed their efforts as having revealed the “genetic architecture”—which is to say the blueprint or design—of same-sex sexual behavior. Stephanie Clare, Patrick R. Grzanka, and Joanna Wuest argue that the 2019 GWAS marks a moment of both flux and continuity: a recognition of sexuality's complexity and contingency alongside a continued affective, ideological, and economic investment in biology's role in telling fundamental truths about behavior and identity. The study's recognition of the complexity of sexuality should not be mistaken as some wish fulfillment of queer theory; rather, the dream of bioessentialism, entangled with its continued production of inequality, is still alive in the postgenomic era.
期刊介绍:
Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance.
Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.