ASSOCIATION OF SERUM VITAMIN D WITH GLYCOSYLATED HEMOGLOBIN LEVELS AND DURATION OF DISEASE IN TYPE-II DIABETES MELLITUS PATIENTS

Objective:  To find a possible association between levels of vitamin D and glycosylated hemoglobin levels in patients with type II diabetes mellitus. Materials and Methods: A cross-sectional study was conducted at a tertiary care hospital in Peshawar over six months. Diagnosed cases of Type-II diabetes mellitus were recruited through non-probability consecutive sampling. The levels of glycosylated hemoglobin and serum vitamin D levels were assessed in 219 selected patients enrolled in the study through Cobas Integra 800 and Enzyme-Linked Immunosorbent Assay respectively. Patients were divided into three categories based on increasing levels of glycosylated hemoglobin. The trend in the levels of vitamin D levels in these categories of increasing HbA1c was identified. Results:                                                                                     Out of 219 Type II diabetic patients, 30.1% (66) were men while 69.9% (153) were women. The mean age was 59.48 ± 9.29 years. Similarly, HbA1c and serum vitamin D, were 9.47 ± 2.88 and 18.63 ± 16.54, respectively. Overall, 59% of the patients were Vitamin D deficient. The decrease in Vitamin D levels was associated with an increase in glycosylated hemoglobin levels (p-value 0.002). CONCLUSION: Vitamin D deficiency in Type-II diabetes mellitus patients increases with increasing levels of glycosylated hemoglobin.   KEYWORDS: Diabetes Mellitus, Type II Diabetes, HBA1c, Vitamin D.