活化外周血单个核细胞法与富血小板血浆人胎盘促性腺激素法对胚胎移植后妊娠成功率的比较

Q4 Medicine pzshkhy blyny bn syn Pub Date : 2020-12-01 DOI:10.29252/AJCM.27.3.133
Mahnaz Yanangi, T. Artimani, Narges Sajedi, J. Poorolajal, Faranak Pour Monsef
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引用次数: 0

摘要

背景与目的:根据一些研究结果,人胎盘促性腺激素激活的外周血单核细胞可提高不孕妇女的妊娠成功率。本研究旨在比较人胎盘促性腺激素和富含血小板的血浆激活外周血单核细胞的两种治疗方法对胚胎移植后妊娠成功率的影响。材料和方法:这项随机临床试验对40名重复植入失败的女性进行,她们是体外受精(IVF)的候选者,并于2019年转诊至伊朗哈马丹的Fatemieh医院。随后,他们被随机分为A组和B组。A组使用人胎盘促性腺激素激活的外周血单核细胞,B组在输血前接受富含血小板的血浆自体血。对两组的化学妊娠和临床妊娠的发生率进行了测量。此外,数据在Stata软件(版本14)中进行了分析,p值小于0.05被认为具有统计学意义。结果:A组和B组女性不育的平均年龄和持续时间分别为32.5岁和34.4岁(P=0.203),以及9.1岁和8.5岁(P=0.747)。此外,A组和B组获得的卵子、形成的胚胎和移植的胚胎的平均数量分别为15.4±11.5和12.9±8.9(P=0.439)、7.1±6.2和5.8±3.8(P=0.427),以及2.3±0.7和2.3±0.6(P=1.00)。此外,A组和B组的化学妊娠率分别为15%和25%(P=0.619),临床妊娠率分别是15%和20%(P=0.581)。结论:在重复植入失败的体外受精女性胚胎移植后,给予人胎盘促性腺激素激活的外周血细胞对富含血小板的血浆妊娠结局显示出相似的结果。
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Comparison of the Activated Peripheral Blood Mononuclear Cells with Human Placental Gonadotropin Method with Platelet-Rich Plasma on Pregnancy Success Rate after Embryo Transfer
Background and Objective: According to the results of some studies, peripheral blood mononuclear cells activated with human placental gonadotropin increase the success rate of pregnancy in infertile women. This study aimed to compare the effect of two treatment methods of peripheral blood mononuclear cells activated with human placental gonadotropin and platelet-rich plasma on the success rate of pregnancy after embryo transfer. Materials and Methods: This randomized clinical trial was conducted on 40 females with repeated implantation failure who were candidates for in vitro fertilization (IVF) and referred to Fatemieh Hospital, Hamadan, Iran, in 2019. Subsequently, they were randomly assigned to two groups of A and B. Peripheral blood mononuclear cells activated with human placental gonadotropin were utilized in group A, and group B received platelet -rich plasma autologous blood before transfusion. The incidence of chemical and clinical pregnancies was measured in both groups. Moreover, the data were analyzed in Stata software (version 14), and a p-value less than 0.05 was considered statistically significant. Results: The mean ages and duration of the infertility of the females were 32.5 and 34.4 years (P=0.203), as well as 9.1 and 8.5 years (P=0.747) in groups A and B, respectively. Moreover, the mean numbers of the obtained ovum, embryos formed, and transferred embryos were 15.4±11.5 and 12.9±8.9 (P=0.439), 7.1±6.2 and 5.8±3.8 (P=0.427), as well as 2.3±0.7 and 2.3±0.6 (P=1.00) in groups A and B, respectively. Furthermore, the rates of chemical pregnancies were 15% and 25% (P=0.619), and clinical pregnancies were 15% and 20% (P=0.581) in groups A and B, respectively. Conclusion: The administration of human placental gonadotropin-activated peripheral blood cells showed similar results on pregnancy outcome with platelet-rich plasma after an embryo transfer in females who were candidates for IVF with repeated implantation failure.
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16
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