单孕酮作为GnRH-a给药的补充治疗机制

Jiming Chen, Junling Liu, Wei-ming Wei, Ying Cao, Yilin Sun, Huichao Xiao, Yafeng Zheng, Yunfen Jiang, Ruxia Shi
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引用次数: 0

摘要

子宫内膜异位症(EMS)是一种常见的雌激素依赖性妇科疾病,影响育龄妇女的生活质量和生育能力。目前EMS的治疗主要基于手术和术后卵巢抑制剂的维持治疗。EMS患者面临的主要挑战是术后复发[2-3]。一些药物治疗已被建议,如口服避孕药,促性腺激素释放激素激动剂(GnRH-a)。GnRH-a是EMS的重要治疗方式,可显著减轻EMS相关症状[4-6]。
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The Mechanism of Single Progesterone as Add-Back Therapy to GnRH-a Administration
Endometriosis (EMS) is a common estrogen-dependent gynecological disorder, which affects quality of life and fertility of productive-aged women [1]. Current treatment of EMS is mainly based on surgery and post-operative maintenance treatment of ovarian suppressive agents. A major challenge for women with EMS is the post-operative recurrence [2-3]. Some medical treatments have been suggested for EMS, such as oral contraceptive pills, and gonadotropin-releasing hormone agonists (GnRH-a). GnRH-a is an important treatment modality for EMS, significantly reducing EMSrelated symptoms [4-6].
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