新型茚丹官能化羟基和氨基甲基膦酸酯的合成

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2018-05-30 DOI:10.1002/hc.21419

Andrey A. Prishchenko, Mikhail V. Livantsov, Olga P. Novikova, Ludmila I. Livantsova, Valery S. Petrosyan

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引用次数: 6

摘要

研究了一种方便合成含吲哚基的新型官能化有机磷酸及其衍生物的方法。二(三甲基硅氧基)膦与吲哚的区域选择性自由基加成得到2-吲哚基膦酸盐，这是制备上述含双环取代基酸的关键化合物。以偶氮铋(异丁腈)(AIBN)在其热裂解条件下作为加成反应的有效引发剂。用甲醇甲醇钠溶液进一步处理有机磷酸三甲基硅酯，得到相应酸的水溶性钠盐。

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Synthesis of new functionalized hydroxy- and aminomethylphosphinates with indan moieties

The convenient synthesis of new functionalized organophosphorus acids and their derivatives containing indan moieties was developed. The regioselective radical addition of bis(trimethylsiloxy)phosphine to indene proceeds to give rise to 2-indanylphosphonite as key compound for preparation of above acids with bicyclic substituents. Azobis(isobutyronitrile) (AIBN) in the conditions of its thermolysis was used as effective initiator of the addition reaction. The further treatment of organophosphorus acids trimethylsilyl esters with the methanolic sodium methoxide solution resulted in the water-soluble sodium salts of the corresponding acids.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.