{"title":"从麻黄茎中分离出一种新的木脂素。","authors":"Weisheng Feng, Xi-ling Fan, Yan-gang Cao, Mengnan Zeng, Ru Wang, Yanling Liu, Chenxiang Xu, Xin-yi Ma, Ying-jie Ren, Chen He, Xiangda Li, Xiaoke Zheng","doi":"10.25135/rnp.359.2207.2519","DOIUrl":null,"url":null,"abstract":": A new lignan eplignan A ( 1 ), along with six konwn lignans ( 2 – 7 ) was isolated from the herbaceous stems of Ephedra intermedia Schrenket C. A. Meyer. Their structures were elucidated based on the spectroscopic evidence, mainly including NMR and HRESIMS data. The absolute configuration of 1 was determined by comparing calculated and experimental electronic circular dichroic (ECD) spectra. Moreover, all compounds ( 1 – 7 ) were evaluated for their protective effects against the BEAS-2B cells injury induced by TGF- β 1 in vitro , and the results showed that compounds 1 , 2 , 4 , and 6 exhibited significantly protective activities at the concentration of 10 μ M.","PeriodicalId":21053,"journal":{"name":"Records of Natural Products","volume":" ","pages":""},"PeriodicalIF":1.5000,"publicationDate":"2022-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":"{\"title\":\"A New Lignan from the Herbaceous stems of Ephedra intermedia Schrenket C. A. Meyer.\",\"authors\":\"Weisheng Feng, Xi-ling Fan, Yan-gang Cao, Mengnan Zeng, Ru Wang, Yanling Liu, Chenxiang Xu, Xin-yi Ma, Ying-jie Ren, Chen He, Xiangda Li, Xiaoke Zheng\",\"doi\":\"10.25135/rnp.359.2207.2519\",\"DOIUrl\":null,\"url\":null,\"abstract\":\": A new lignan eplignan A ( 1 ), along with six konwn lignans ( 2 – 7 ) was isolated from the herbaceous stems of Ephedra intermedia Schrenket C. A. Meyer. Their structures were elucidated based on the spectroscopic evidence, mainly including NMR and HRESIMS data. The absolute configuration of 1 was determined by comparing calculated and experimental electronic circular dichroic (ECD) spectra. Moreover, all compounds ( 1 – 7 ) were evaluated for their protective effects against the BEAS-2B cells injury induced by TGF- β 1 in vitro , and the results showed that compounds 1 , 2 , 4 , and 6 exhibited significantly protective activities at the concentration of 10 μ M.\",\"PeriodicalId\":21053,\"journal\":{\"name\":\"Records of Natural Products\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":1.5000,\"publicationDate\":\"2022-10-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Records of Natural Products\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.25135/rnp.359.2207.2519\",\"RegionNum\":4,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, APPLIED\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Records of Natural Products","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.25135/rnp.359.2207.2519","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
A New Lignan from the Herbaceous stems of Ephedra intermedia Schrenket C. A. Meyer.
: A new lignan eplignan A ( 1 ), along with six konwn lignans ( 2 – 7 ) was isolated from the herbaceous stems of Ephedra intermedia Schrenket C. A. Meyer. Their structures were elucidated based on the spectroscopic evidence, mainly including NMR and HRESIMS data. The absolute configuration of 1 was determined by comparing calculated and experimental electronic circular dichroic (ECD) spectra. Moreover, all compounds ( 1 – 7 ) were evaluated for their protective effects against the BEAS-2B cells injury induced by TGF- β 1 in vitro , and the results showed that compounds 1 , 2 , 4 , and 6 exhibited significantly protective activities at the concentration of 10 μ M.
期刊介绍：
Records of Natural Products is a journal of natural product chemistry. Reviews, book reviews, research papers and short reports are considered on the substances of plants, microbes and animals.
Discussions on the structure elucidation, synthesis of naturally occurring compounds and biological activity of natural compounds and plant extracts, biosynthesis of natural products and essential oils of aromatic plants as well as chemotaxonomy in the field of plants are welcomed in the journal.
All published research articles in Records of Natural Products have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by expert referees.
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