Outcomes of pancreatic resection for elderly patients with pancreatic cancer

BackgroundPancreatic ductal adenocarcinoma (PDAC) is a lethal disease with poor, albeit gradually improving, prognosis. We evaluated predictive clinicophysiological outcomes of elderly patients with PDAC.MethodsWe retrospectively examined 260 patients who underwent pancreatic resection classified into two groups: (A) those ≤ 80 (B) and those > 80 years. Operative characteristics, preoperative clinicophysiological parameters (body mass index, jaundice decompression, total bilirubin, albumin, creatinine, HbA1c, amylase, C-reactive protein, white blood cells, lymphocytes, hemoglobin, platelets, cancer antigen 19-9, carcinoembryonic antigen, neutrophil/lymphocyte ratio, prognostic nutritional index, platelet/lymphocyte ratio, and CRP/Alb ratio), disease-free survival (DFS), and overall survival (OS) were reported.ResultsThere were no differences noted in morbidity, mortality, and preoperative clinicophysiological parameters. Median DFS of groups A and B were 15.4 and 15.5 months respectively. One year and 3-year OS of groups A and B were 86.7/68% and 88.4/69.3%, respectively. There were no differences between the groups for DFS and OS.ConclusionCurative resection for PDAC can be safely performed in elderly and younger patients and elderly patients with PDAC can benefit from curative surgery without a significant decrease in survival rates.